Department of Physiology

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Morphological and Histochemical Investigation of the Role (S) of Moringa Oleifera (Lam) on 3- Nitropropionic Acid Model of Huntington’s disease
(2020-11-10) Ogundipe, Oluwadare
Abstract: Aim: This study evaluated the role of Moringe Oleifera (MO) in the treatment of Huntington's disease induced by 3- Nitropropionic Acid (3-NP). Material and Method: Forty adult mice weighting between 25-32g were used and divided into four groups (A, B, C and D), Group A serves as the control (Received food and ad libitum), B (Received MO+3-NP), C (Received only 3-NP) and D (Received 3-NP + MO). 3- Nitropropionic Acid (20mg/kg) was administered to the animals intraperitoneal for 7 days. MO was administered orally (250mg/kg) for a period of 7 days. Weights of the animals were monitored periodically using the digital weighing balance. Animals were sacrificed at the end of the experiment and the brain tissue was excised for morphological and histochemical study. Results showed cyto-architecture derangement of the brain tissue in the Huntington's group, while the preventive group showed some degree of preservation of the tissue architecture. Conclusion: 3-Np induced huntington's disease model in mice as expected with the characteristics of demyelination, chromatolysis, exaggerated protein clumps aggregations on the tissue organ and Moringa oleifera shows little curative effect on the neuronal neuro-degeneration.