Morphological and Histochemical Investigation of the Role (S) of Moringa Oleifera (Lam) on 3- Nitropropionic Acid Model of Huntington’s disease
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Date
2020-11-10
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Abstract
Abstract: Aim: This study evaluated the role of Moringe Oleifera
(MO) in the treatment of Huntington's disease induced by 3-
Nitropropionic Acid (3-NP). Material and Method: Forty adult
mice weighting between 25-32g were used and divided into four
groups (A, B, C and D), Group A serves as the control (Received
food and ad libitum), B (Received MO+3-NP), C (Received only
3-NP) and D (Received 3-NP + MO). 3- Nitropropionic Acid
(20mg/kg) was administered to the animals intraperitoneal for 7
days. MO was administered orally (250mg/kg) for a period of 7
days. Weights of the animals were monitored periodically using
the digital weighing balance. Animals were sacrificed at the end
of the experiment and the brain tissue was excised for
morphological and histochemical study.
Results showed cyto-architecture derangement of the brain tissue
in the Huntington's group, while the preventive group showed
some degree of preservation of the tissue architecture.
Conclusion: 3-Np induced huntington's disease model in mice as
expected with the characteristics of demyelination,
chromatolysis, exaggerated protein clumps aggregations on the
tissue organ and Moringa oleifera shows little curative effect on
the neuronal neuro-degeneration.
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Keywords
huntington's disease, 3-Nitropropionic acid, Moringa,