Amine-Modified Kaolinite Clay Preserved Thyroid Function and Renal Oxidative Balance after Sub-Acute Exposure in Rats

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dc.contributor.authorAvwioroko, Oghenetega
dc.date.accessioned2022-09-15T12:16:09Z
dc.date.available2022-09-15T12:16:09Z
dc.date.issued2020
dc.description.abstractObjectives: Kaolinite clay is an abundant natural resource in Nigeria with several industrial applications. Incidentally, the wide-scale use of kaolinite clay is hampered by its small surface area. The objective of this study was to assess the effects of amine-modified clay on electrolyte, thyroid, and kidney function markers. Methods: Modification of kaolinite clay with an amine functional group was achieved using surface grafting technique. Characterization with a scanning electron microscope and Brunauer-Emmett Teller surface area analyzer confirmed this modification. However, there is sparse information on the effect of amine-modified kaolinite clay on electrolyte homeostasis, thyroid, and renal function. Rats were administered amine-modified kaolinite clay at the doses of 1, 2, and 5 mg/kg body weight. Results: After 14 days of repeated-dose treatment, there were no significant changes in levels of albumin, uric acid, triiodothyronine, thyroxine, ratio of triiodothyronine to thyroxine, and relative kidney organ weight. Furthermore, there were no changes in the concentration of potassium, although amine modified kaolinite clay significantly decreased sodium, calcium, and total cholesterol levels. Amine modified kaolinite clay, at all treatment doses, also preserved the renal histoarchitecture and oxidative balance in rats. Conclusions: This study reports on the effect of aminemodified kaolinite clay on renal markers and thyroid function, and further deepens our understanding of their biochemical action. This baseline data may boost the prospect of using amine-modified kaolinite clay in the treatment of contaminated water.en_US
dc.identifier.issnhttps://doi.org/10.1515/jbcpp-2019-0298
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/3640
dc.language.isoenen_US
dc.publisherJ Basic Clin Physiol Pharmacolen_US
dc.subjectAmine-modified kaolinite clayen_US
dc.subjectElectrolytesen_US
dc.subjectKidneyen_US
dc.subjectRatsen_US
dc.subjectThyroid functionen_US
dc.titleAmine-Modified Kaolinite Clay Preserved Thyroid Function and Renal Oxidative Balance after Sub-Acute Exposure in Ratsen_US
dc.typeArticleen_US
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