Amine-Modified Kaolinite Clay Preserved Thyroid Function and Renal Oxidative Balance after Sub-Acute Exposure in Rats
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Date
2020
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J Basic Clin Physiol Pharmacol
Abstract
Objectives: Kaolinite clay is an abundant natural resource in Nigeria with several industrial applications.
Incidentally, the wide-scale use of kaolinite clay is hampered by its small surface area. The objective of
this study was to assess the effects of amine-modified clay on electrolyte, thyroid, and kidney function
markers.
Methods: Modification of kaolinite clay with an amine functional group was achieved using surface
grafting technique. Characterization with a scanning electron microscope and Brunauer-Emmett Teller
surface area analyzer confirmed this modification. However, there is sparse information on the effect of
amine-modified kaolinite clay on electrolyte homeostasis, thyroid, and renal function. Rats were
administered amine-modified kaolinite clay at the doses of 1, 2, and 5 mg/kg body weight.
Results: After 14 days of repeated-dose treatment, there were no significant changes in levels of
albumin, uric acid, triiodothyronine, thyroxine, ratio of triiodothyronine to thyroxine, and relative kidney
organ weight. Furthermore, there were no changes in the concentration of potassium, although amine modified kaolinite clay significantly decreased sodium, calcium, and total cholesterol levels. Amine modified kaolinite clay, at all treatment doses, also preserved the renal histoarchitecture and oxidative
balance in rats.
Conclusions: This study reports on the effect of aminemodified kaolinite clay on renal markers and
thyroid function, and further deepens our understanding of their biochemical action. This baseline data
may boost the prospect of using amine-modified kaolinite clay in the treatment of contaminated water.
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Keywords
Amine-modified kaolinite clay, Electrolytes, Kidney, Rats, Thyroid function