Cerebellar Cortex and the Behaviour of Mice (Mus Musculus) Following the Administration of Palm Wine
| dc.contributor.author | Ogundipe, Oluwadare | |
| dc.date.accessioned | 2022-01-25T13:00:24Z | |
| dc.date.available | 2022-01-25T13:00:24Z | |
| dc.date.issued | 2020-08-07 | |
| dc.description.abstract | Abstract: Aim:-To investigates the histomorphological studies of the cerebellar cortex and the behaviour of mice after palm wine administration. Material and Method:- 40 adult mice (25-30g) were grouped into (A, B, C and D) comprised of 10 mice each. They were kept in plastic cages and fed with feed and water ad libitum. Group A (control group) received distilled water, group B ,C and D received 14.3ml/kg daily palm wine,14.3ml/kg palm wine every other day and 14.3ml/kg 50% diluted palm wine every other day respectively, orally for four weeks. They were weighted using weighing balance, the neurobehavioral evaluation was performed using the open field maze and the health status was appraised by the rectal temperature. After the last dose of administration, the animals were anaesthetized; the cerebellum was excised, weighed and fixed in 10% formal saline for H&E, Cresyl fast violet and bieschowsky silver stain techniques. Data were analyzed using one way ANOVA at p<0.05 followed by a posthoc test, results were expressed as mean S.E.M. Results;- decrease in the rectal temperature of the entire treated group when compared to the control group, relative weight of the cerebellum was higher in the treated group compared to control, neurobehavioral observations (motor parameters) showed difference between treated mice compared to control. Histological observations showed vacuolation and slight degeneration of Purkinje neuron cell bodies except in group D animals. Conclusion:- The study showed that palm wine intake on regular basis may affect the histoarchitecture of the cerebellum, neurobehavioural activities such as locomotion and balancing | en_US |
| dc.description.sponsorship | self | en_US |
| dc.identifier.issn | 2708-3594 | |
| dc.identifier.uri | http://dspace.run.edu.ng:8080/jspui/handle/123456789/844 | |
| dc.language.iso | en | en_US |
| dc.title | Cerebellar Cortex and the Behaviour of Mice (Mus Musculus) Following the Administration of Palm Wine | en_US |
| dc.type | Article | en_US |