Natural Honey Reduced Atherogenic and Coronary Risk Indices in Wistar Rats

Simple item page
dc.contributor.authorOlukanni, Adedayo
dc.date.accessioned2022-05-07T13:23:57Z
dc.date.available2022-05-07T13:23:57Z
dc.date.issued2020-01
dc.description.abstractThe biochemical mechanism underlying the nutraceutical effects of honey is poorly understood, thus making its functions more a matter of speculations. In this study, we investigated the effects of honey on the atherogenic and coronary risk indices in Wistar rats. An experimental design comprising two groups of rats fed with normal rat chow but with the experimental group receiving 10% honey in water and the control group water alone, for five weeks. Blood samples were collected weekly from each group, and the level of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and total protein were determined. The lipids profile (total cholesterol, total triglycerides, LDL and HDL) were also determined, and the atherogenic and coronary indices were estimated. Data were analyzed, and p<0.05 was considered significant. There were no significant changes in both groups’ serum SOD and CAT across the weeks of study. The LDL cholesterol of the honey-treated rats, however, decreased significantly (9.95 mg/dL) compared to the controls (27.07 mg/dL) (p=0.000). In contrast, honey intake elevated the HDL cholesterol (18.37 mg/dL) relative to 12.25 mg/dL in the control group (p=0.003). Consequently, honey treatment caused significant depletion of atherogenic and coronary risk indices (76.13%, p=0.001) and (50.37%, p=0.023) respectively. We show evidence that the regular intake of honey, at a concentration as low as ten percent of total water intake, may lower factors for the onset of hypertension and coronary diseases.en_US
dc.identifier.issn2407-2230
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/2808
dc.language.isoenen_US
dc.publisherFaculty of Medicine Trisakti Universityen_US
dc.subjectHoneyen_US
dc.subjectAtherosclerosisen_US
dc.subjectCoronary risken_US
dc.subjectAnti-oxidanten_US
dc.subjectRatsen_US
dc.subjectOxidative stressen_US
dc.titleNatural Honey Reduced Atherogenic and Coronary Risk Indices in Wistar Ratsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Natural honey reduced atherogenic and coronary risk indices in wistar rats.pdf
Size:
1.52 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Department of Biochemistry