Natural Honey Reduced Atherogenic and Coronary Risk Indices in Wistar Rats
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Date
2020-01
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Faculty of Medicine Trisakti University
Abstract
The biochemical mechanism underlying the nutraceutical effects of honey
is poorly understood, thus making its functions more a matter of
speculations. In this study, we investigated the effects of honey on the
atherogenic and coronary risk indices in Wistar rats.
An experimental design comprising two groups of rats fed with normal rat
chow but with the experimental group receiving 10% honey in water and
the control group water alone, for five weeks. Blood samples were collected
weekly from each group, and the level of superoxide dismutase (SOD),
catalase (CAT), reduced glutathione (GSH) and total protein were
determined. The lipids profile (total cholesterol, total triglycerides, LDL
and HDL) were also determined, and the atherogenic and coronary indices
were estimated. Data were analyzed, and p<0.05 was considered significant.
There were no significant changes in both groups’ serum SOD and CAT
across the weeks of study. The LDL cholesterol of the honey-treated rats,
however, decreased significantly (9.95 mg/dL) compared to the controls
(27.07 mg/dL) (p=0.000). In contrast, honey intake elevated the HDL
cholesterol (18.37 mg/dL) relative to 12.25 mg/dL in the control group
(p=0.003). Consequently, honey treatment caused significant depletion of
atherogenic and coronary risk indices (76.13%, p=0.001) and (50.37%,
p=0.023) respectively. We show evidence that the regular intake of honey, at a concentration as
low as ten percent of total water intake, may lower factors for the onset of
hypertension and coronary diseases.
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Keywords
Honey, Atherosclerosis, Coronary risk, Anti-oxidant, Rats, Oxidative stress