Polyphenol-rich extract of Vernonia amygdalina (Del.) leaves ameliorated cadmium-induced alterations in feeding pattern and urine volume of male Wistar rats
| dc.contributor.author | Ogundipe, Oluwadare | |
| dc.date.accessioned | 2022-01-25T13:03:03Z | |
| dc.date.available | 2022-01-25T13:03:03Z | |
| dc.date.issued | 2015-11-13 | |
| dc.description.abstract | Aim: To determine the effects of polyphenol-rich extract of the leaves of Vernonia amygdalina (PEVA) on the feeding pattern of rats that were exposed to cadmium (Cd) toxicity. Materials and Methods: Thirty male Wistar rats, weighing 160-180 g, were divided into 6 groups of 5 rats each as follows; Group 1 received distilled water orally (0.2 ml/100 g), daily, throughout the period of study. Group 2 received Cd alone (in the form of CdSO4) at 5 mg/kg/day via intraperitoneal route for 5 consecutive days. Group 3 were pre-treated with Cd as Group 2 and thereafter left untreated for a period of 4-week. After the oral lethal dose of PEVA was determined, Groups 4, 5, and 6 were pre-treated with Cd as Group 2 after which they received graded doses of PEVA at 100, 200 and 400 mg/kg/day (0.2 ml/100 g), respectively via oral route for 4 weeks. Blood samples were collected for some plasma biochemical assays while urine samples were collected using metabolic cages. Results: PEVA administration significantly increased (P < 0.05) the body weight and feeding patterns that were significantly reduced (P < 0.05) by Cd toxicity. PEVA also significantly reinstated the plasma antioxidant status, as well as glucose and urine volume of the rats toward control values (P < 0.05). Conclusion: PEVA can be an herbal alternative in the treatment or management of subjects manifesting alterations in feeding pattern and urine volume that is Cd-induced | en_US |
| dc.description.sponsorship | self | en_US |
| dc.identifier.uri | http://dspace.run.edu.ng:8080/jspui/handle/123456789/846 | |
| dc.language.iso | en | en_US |
| dc.publisher | ScopeMed | en_US |
| dc.title | Polyphenol-rich extract of Vernonia amygdalina (Del.) leaves ameliorated cadmium-induced alterations in feeding pattern and urine volume of male Wistar rats | en_US |
| dc.type | Article | en_US |