Neuroprotective Activity of Ipomoea cairica Leaf Extract against Cadmium Chloride-Induced Biochemical Changes in the Brain of Male Wistar Rats

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dc.contributor.authorAvwioroko, Oghenetega
dc.date.accessioned2022-09-15T12:16:22Z
dc.date.available2022-09-15T12:16:22Z
dc.date.issued2022
dc.description.abstractBackground: Exposure to cadmium is implicated in the etiology of some neurodegenerative diseases. Compounds isolated from Ipomoea cairica extract are neuroprotective. However, there is no reported neuroprotective activity of the crude extract of I. cairica (ICE). We investigated the neuroprotective activity of I. cairica extract against cadmiuminduced biochemical changes in the brain of male Wistar rats. Thirty-six animals were divided into four groups of 9 animals per group: group I (Control); group II (3.5 mg/kg CdCl2); group III (100 mg/kg ICE+ CdCl2); and group IV (250 mg/kg ICE+ CdCl2). Animals were pretreated with 100 and 250 mg/kg ICE before co-administration with cadmium chloride. Results: CdCl2 treatment caused a signifcant increase in acetylcholineesterase activity, lipid peroxidation, beta-amy- loid aggregation, caspase 3 and 9, p53, and glutamate concentration. In addition, CdCl2 caused a signifcant decrease in catalase activity, superoxide dismutase, glutathione-S-transferase, Na+/K+ ATPase, and glutamate dehydrogenase. ICE was able to reduce the neuronal damaging efect of CdCl2 by acting as an antioxidant, antiapoptotic, anticho- linesterase, and antiexcitotoxicity. Conclusions: Our findings show that Ipomoea cairica leaf can be developed and included in the natural product in the prevention of neurodegenerative diseases.en_US
dc.identifier.issnhttps://doi.org/10.1186/s42269-022-00749-5
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/3641
dc.language.isoenen_US
dc.publisherBulletin of the National Research Centreen_US
dc.subjectCadmiumen_US
dc.subjectNeurotoxicityen_US
dc.subjectNatural producten_US
dc.subjectOxidative stressen_US
dc.subjectBeta-amyloiden_US
dc.subjectGlutamateen_US
dc.subjectIpomoea cairicaen_US
dc.titleNeuroprotective Activity of Ipomoea cairica Leaf Extract against Cadmium Chloride-Induced Biochemical Changes in the Brain of Male Wistar Ratsen_US
dc.typeArticleen_US
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