Neuroprotective Activity of Ipomoea cairica Leaf Extract against Cadmium Chloride-Induced Biochemical Changes in the Brain of Male Wistar Rats
Loading...
Date
2022
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Bulletin of the National Research Centre
Abstract
Background: Exposure to cadmium is implicated in the etiology of some neurodegenerative diseases.
Compounds isolated from Ipomoea cairica extract are neuroprotective. However, there is no reported
neuroprotective activity of the crude extract of I. cairica (ICE). We investigated the neuroprotective
activity of I. cairica extract against cadmiuminduced biochemical changes in the brain of male Wistar
rats. Thirty-six animals were divided into four groups of 9 animals per group: group I (Control); group II
(3.5 mg/kg CdCl2); group III (100 mg/kg ICE+ CdCl2); and group IV (250 mg/kg ICE+ CdCl2). Animals were
pretreated with 100 and 250 mg/kg ICE before co-administration with cadmium chloride.
Results: CdCl2 treatment caused a signifcant increase in acetylcholineesterase activity, lipid peroxidation,
beta-amy- loid aggregation, caspase 3 and 9, p53, and glutamate concentration. In addition, CdCl2
caused a signifcant decrease in catalase activity, superoxide dismutase, glutathione-S-transferase,
Na+/K+ ATPase, and glutamate dehydrogenase. ICE was able to reduce the neuronal damaging efect of
CdCl2 by acting as an antioxidant, antiapoptotic, anticho- linesterase, and antiexcitotoxicity.
Conclusions: Our findings show that Ipomoea cairica leaf can be developed and included in the natural
product in the prevention of neurodegenerative diseases.
Description
Keywords
Cadmium, Neurotoxicity, Natural product, Oxidative stress, Beta-amyloid, Glutamate, Ipomoea cairica