Histomophological Study of Aqueous Extract of Hibiscus Sabdariffa on Hormonally Induced Prostatic Enlargement of Adult Wistar Rat
| dc.contributor.author | Ogundipe, Oluwadare | |
| dc.date.accessioned | 2022-01-25T13:02:24Z | |
| dc.date.available | 2022-01-25T13:02:24Z | |
| dc.date.issued | 2019-12-07 | |
| dc.description.abstract | Abstract: - Aim: to investigate some effects of aqueous extract of Hibiscus sabdariffa on induced benign prostatic hyperplasia. Material and Method: Forty eight male adult wistar rats weighing between 190g and 220g were used for the study. They were acclimatized for 2 weeks and fed with standard rat chow and water ad libitum before the study. They were divided into six groups. Group1- control group received 0.3ml of corn oil, others were induced for BPH with hormones (200µg Testosterone and 100µg estradiol) for 3 weeks; after induction Group 2 took distilled water, Group 3 received 0.71g of finasteride, Group 4, 5 and 6 received 0.3, 0.6 and 0.9g/kg bw Hibiscus sabdariffa (HS), respectively. The prostate were excised, processed and stained with H&E and Masson Trichrome. Result: The weight of group 4, 5 and 6 rats decrease compared to group 2 rats. There were pronounced reduction in the mucosal (epithelial) and fibromuscular stroma hyperplasia of the treated groups when compared with the group 2 rats. Conclusion: This indicates that the test herb has no adverse effect on prostatic parameters of healthy rats and also shows that Hibiscus sabdariffa extract can be viewed as a candidate novel medication for benign prostate hyperplasia therapy. | en_US |
| dc.description.sponsorship | self | en_US |
| dc.identifier.issn | 2321–2705 | |
| dc.identifier.uri | http://dspace.run.edu.ng:8080/jspui/handle/123456789/845 | |
| dc.language.iso | en | en_US |
| dc.title | Histomophological Study of Aqueous Extract of Hibiscus Sabdariffa on Hormonally Induced Prostatic Enlargement of Adult Wistar Rat | en_US |
| dc.type | Article | en_US |