Histomophological Study of Aqueous Extract of Hibiscus Sabdariffa on Hormonally Induced Prostatic Enlargement of Adult Wistar Rat
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Date
2019-12-07
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Abstract
Abstract: - Aim: to investigate some effects of aqueous extract of
Hibiscus sabdariffa on induced benign prostatic hyperplasia.
Material and Method: Forty eight male adult wistar rats
weighing between 190g and 220g were used for the study. They
were acclimatized for 2 weeks and fed with standard rat chow
and water ad libitum before the study. They were divided into six
groups. Group1- control group received 0.3ml of corn oil, others
were induced for BPH with hormones (200µg Testosterone and
100µg estradiol) for 3 weeks; after induction Group 2 took
distilled water, Group 3 received 0.71g of finasteride, Group 4, 5
and 6 received 0.3, 0.6 and 0.9g/kg bw Hibiscus sabdariffa (HS),
respectively. The prostate were excised, processed and stained
with H&E and Masson Trichrome. Result: The weight of group
4, 5 and 6 rats decrease compared to group 2 rats. There were
pronounced reduction in the mucosal (epithelial) and
fibromuscular stroma hyperplasia of the treated groups when
compared with the group 2 rats. Conclusion: This indicates that
the test herb has no adverse effect on prostatic parameters of
healthy rats and also shows that Hibiscus sabdariffa extract can
be viewed as a candidate novel medication for benign prostate
hyperplasia therapy.