Ocimum Gratissimum Linn. Leaf Extract and Fractions Pre-Treatments are not Associated With Deleterious Electrocardiogram Changes in Trastuzumab Intoxicated Wistar Rats
No Thumbnail Available
Date
2024-06-15
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Al-Nahrain Journal of Science
Abstract
Trastuzumab (TZM) treatment is known to be associated with
arrhythmogenic potential which primarily is the basis for its
cardiotoxicity. The purpose of this study was to investigate the acute
influence of oral pretreatments with 100 mg/kg/day of Ocimun
gratissimum ethanolic leaf extract (OG) and its fractions (petroleum ether,
PEOG; ethyl acetate, EAOG; and ethanolic extract, EOG) as well as
valsartan-lisinopril fixed dose combination (VAL-LSP) on
electrocardiogram (ECG) of Wistar rats intaperitoneally treated with 2.25
mg/kg/day TZM for 7 days. Young adult male Wistar rats were randomly
allotted into 12 groups of 6 rats per group. The rats were subjected to
electrocardiograms (ECG) measurement using non-invasive procedures on
days 1 and 7 of the experiment. Results showed that oral pretreatment
with OG and its fractions (except EOG) as well as VAL-LSP fixed dose
combination did not cause any remarkable changes in the ECG patterns of
TZM-treated rats indicating that their relative oral safety in TZM
chemotherapy. On the other hand, EOG pretreatment caused significant
shortening of the OT/QTc interval in the TZM-treated rats highlighting
the arrhthymogenic potential of this fraction. Overall, the study
highlighted the arrhythmogenic potential of EOG in TZM chemotherapy
while OG and its other solvent fractions as well as VAL-LSP could be
considered relatively safe for use as adjuvants in TZM chemotherapy.