Preclinical investigation on the antinociceptive, antipyretic, antiinflammatory and antioxidant activities of Ananas comosus leaf extract
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Date
2025-03-01
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Journal of Basic and Applied Pharmacology
Abstract
Ananas comosus is a well-known medicinal plant used in traditional medicine for various
therapeutic purposes, including the treatment of pain, fever and inflammation. This study aimed to
evaluate the antinociceptive, anti-inflammatory, antipyretic and antioxidant activities of the
ethanolic leaf extract of A. comosus and the mechanism by which it produces its antinociceptive
effects in mice. The antinociceptive activity of ethanolic leaf extract of A. comosus was evaluated
using an acetic acid-induced writhing test and a formalin-induced pain test. The mechanism of anti nociception was determined by pretreating mice with various antagonists (naloxone,
glibenclamide, atropine, nifedipine and theophyline) before administration of the extract (800
mg/kg) during the acetic acid-induced writhing test. The antipyretic effect was evaluated using
yeast-induced pyrexia in mice, while formalin-induced inflammation was used to evaluate the anti inflammatory effects. The extract demonstrated potent antinociceptive activity compared to the
control group in the acetic acid-induced writhing test and in the formalin-induced pain models.
Naloxone, glibenclamide, atropine and nifedipine did not block the antinociceptive activity.
However, theophylline significantly reversed the antinociceptive effect in the acetic acid-induced
writhing test. The extract also showed antipyretic and anti-inflammatory effects, while the results
of the antioxidant study showed that it has high antioxidant properties. The study results showed
that the extract has potent antinociceptive, antipyretic, anti-inflammatory and antioxidant effects.