Proximate and Phytochemical Composition of Cola lateritia Seeds and its Effect on Lipid Profile Levels in Wistar Albino Rats
No Thumbnail Available
Date
2022-10-17
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
SciTechnol
Abstract
Cola lateritia is an indigenous edible tropical fruit species also
utilized for health purposes. This study was aimed at
determining the proximate, phytochemical composition of Cola
lateritia seeds and its effect on serum lipid profile levels.
Proximate composition and phytochemical analysis were done
using standard methods. Crude extraction protocol was done
using standard methods. Sixteen albino rats were randomly
divided into four groups of four animals each. Group A was the
control group fed on food and water only, Group B, C and D
received 100 mg/kg, 200 mg/kg and 300 mg/kg respectively per
body weight of Cola lateritia seeds extract orally for fourteen
days. Serum levels of High Density Lipoprotein (HDL), Low
Density Lipoprotein (LDL), Triglycerides (TG) and cholesterol
were determined spectrophotometrically. Results showed that
Cola lateritia seeds contained 9.44% moisture, 0.64% ash,
0.20% fat, 1.31% fiber, 6.02% protein and 82.39%carbohydrate.
Preliminary phytochemical screening revealed the presence of
flavonoid (8.35%), saponin (6.59%), terpenoid (5.59%), phenol
(2.53%) and tannin (0.098 mg/g). There was a significant
(p<0.05) reduction in the serum levels of cholesterol, HDL, LDL
and triglycerides in the test groups compared to the control.
These findings thereby suggest the hypolipidemic activity of
Cola lateritia which can be attributed to some of its
phytochemical constituents.
Description
Research article