Chemotherapeutic Potential of Carthamus oxycantha Root Extract as Antidiarrheal and in vitro Antibacterial Activities

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dc.contributor.authorOlukanni, Adedayo
dc.date.accessioned2022-04-27T09:25:53Z
dc.date.available2022-04-27T09:25:53Z
dc.date.issued2020
dc.description.abstractOur research work was designed to investigate the curative and preventive effects of Carthamus oxycantha root extract against diarrhea and microorganisms. For the antibacterial experiment, the agar well diffusion method was used against standard bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, and Salmonella typhi, while for the assessment of antidiarrheal activity, castor oil and the magnesium sulfate-induced diarrhea method was used on albino, laboratory-bred (BALB/c) mice at a dose rate of 200 and 400 mg/kg (body weight, b.w) orally. The methanol extract of C. oxycantha significantly (p < 0.001) decreased the frequency of defecation, and wet stools in a dose depended on the manner of after receiving magnesium sulfate (2 g/kg (b.w)) and castor oil (1.0 mL/mice). Furthermore, the extract of C. oxycantha showed concentration-dependent antimicrobial properties against S. aureus followed by S. typhi, E. coli, and P. aeroginosa bacterial strains, with inhibitions ranging from 10.5–15 mm. These findings show significant results that C. oxycantha is effective as an antidiarrheal and antibacterial agent. However, further works are needed to establish its mode of action.en_US
dc.description.sponsorshipDeanship of Scientific Research at King Saud Universityen_US
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/2447
dc.language.isoenen_US
dc.publisherMultidisciplinary Digital Publishing Instituteen_US
dc.subjectAntibacterial activityen_US
dc.subjectAntidiarrhealen_US
dc.subjectMethanolic extracten_US
dc.subjectCarthamus oxycanthaen_US
dc.subjectMICen_US
dc.titleChemotherapeutic Potential of Carthamus oxycantha Root Extract as Antidiarrheal and in vitro Antibacterial Activitiesen_US
dc.typeArticleen_US
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