Hepatotoxic Effect of Potassium Bromate on the Liver of Wistar Rats
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Date
2013-01-12
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IISTE
Abstract
in the bread-making process as well as a dough conditioner for flour. It is generated as a contaminant in
drinking water due to conversion of bromide found naturally in water to bromate by ozone which is used as
disinfectant. Materials and Methods: Thirty animals were randomly divided into six groups, five rats each.
The treated groups received potassium bromate in drinking water for 21 days. Control group received distilled
water and feed, group one, received 140 mg/L of KBrO3 in drinking water for 3 week, group two: This group
contained 10 rats which were divided into two group containing 5 rats each i.e. group A & B. The rats in
Group 2A and 2B received 170 mg/L of KBrO3 in drinking water, thereafter, KBrO3 was withdrawn from the
animals in group 2B for another 2 weeks, group three received 200 mg/L of KBrO3 in drinking water for 3
weeks, group four: This group contained 5 rats which received KBrO3 at dose level of 200mg/L in drinking
water with co – administration of vitamin E through oral route for 3 weeks. Results: The histology results
revealed distortion in tissue architecture, congestion of the central vein and sinusoidal dilatation as well as cell
necrosis in all the treatment. Conclusion: The use of KBrO3 in edibles may not be advisable as it is not liver
friendly.
Description
Keywords
Histology, Sinusoidal, Necrosis, Potassium bromate
Citation
Olutoyin, Oyewo & Onyije, Felix & Awoniran, Paul. (2013). Hepatotoxic Effect of Potassium Bromate on the Liver of Wistar Rats. Journal of Morphological Sciences. 30. 107-114.