Chemopreventive and Remediation Effect of Hydrocotyl bonariensis Comm. Ex Lam (Apiaceae) Leave Extract in Galactose-induced Cataract
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Date
2009-05-04
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Elsevier
Abstract
Ethnopharmacological relevance: Hydrocotyl bonariensis Comm. Ex Lam (Apiaceae) is being widely used in
Western Nigeria in treating various symptoms of ophthalmic diseases; however scientific data in support
of this medicinal use have not been reported.
Aim of the study: This study, investigated the efficacy of Hydrocotyl bonariensis leave extract in offering
protection against experimental cataract and also examined its remediation effect when administered
after cataract onset.
Materials and methods: Weanling albino rats fed with 30% galactose diet were used in the study. Mechanisms of action of the extract were investigated by measuring the degree of lens peroxidation, lens
antioxidant status and lens protein concentration. Severity of cataract was determined by measuring the
cataract index.
Results: The extract at 500 mg kg−1 reduced cataract index significantly and also reduced cataract progression when administered after cataract onset. Administration of this dosage also significantly reduced the
degree of lens peroxidation, increased the level of reduced glutathione (GSH) and the lens catalase and
superoxide dismutase activity. The extract also prevents protein insolubilization. Administration of the
extract at 1000 mg kg−1 reduced cataract index and lens peroxidation but did not increase the antioxidant
status significantly. Administration of the extract after cataract onset reduced cataract index, moderately
increased percentage soluble protein above the value prior to the arrest of hypergalactosemia but did not
increase the antioxidant status.
Conclusion: Our study suggests that Hydrocotyl bonariensis protects against galactose-induced cataract,
and that administration of the extract after cataract onset reduced cataract progression but did not reverse
cataractogenesis.
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Keywords
Cataract index, Lens oxidation, Antioxidant
Citation
Ajani, E.O., Salako, A.A., Sharlie, P.D., Akinleye, W.A., Adeoye, A.O., Salau, B.A. and Adebawo, O.O., 2009. Chemopreventive and remediation effect of Hydrocotyl bonariensis Comm. Ex Lam (Apiaceae) leave extract in galactose-induced cataract. Journal of ethnopharmacology, 123(1), pp.134-142.