Protective Effects of Methanolic Stem Bark Extract of Commiphora kerstingii Engl. on Pancytopenia and Hyperlipidemia Induced with CdCl2 in Male Wistar Rats
| dc.contributor.author | Ogundipe, Oluwadare | |
| dc.date.accessioned | 2022-01-25T13:09:04Z | |
| dc.date.available | 2022-01-25T13:09:04Z | |
| dc.date.issued | 2022-01-03 | |
| dc.description.abstract | Background and Objective: Commiphora kerstingii (Burseraceae) is a medicinal plant with extensive health benefits and is used traditionally to cure arrow poisons. Scientific studies have reported its antimicrobial, hypoglycemic, anticonvulsant and antioxidant properties. However, its protective effect against Cadmium compounds induced hyperlipidemia and pancytopenia are scanty in literature. The study investigated the protective effect of methanolic stem bark extract of Commiphora kerstingii (MSBECK) on pancytopenia and hyperlipidemia induced with Cadmium chloride in males Wistar rats. Materials and Methods: Thirty-five male Wistar rats were divided into 5 groups, containing seven rats each. Group A was given distilled water, while group B [5 mg/kg/b.wt. of Cadmium chloride (CdCl2)], group C [5 mg/kg/b.wt. of CdCl2+200 mg/kg/b.wt. of MSBECK], group D [5 mg/kg/b.wt. of CdCl2+400 mg/kg/b.wt. of MSBECK], while group E received 400 mg/kg/b.wt. of MSBECK only. All administration was done orally for 14 days. Results: The administration of Cadmium chloride caused a significant (p<0.05) reduction in blood cells and HDL-cholesterol levels. In contrast, it created a considerable increase in the concentration of serum total cholesterol, LDL-cholesterol, triglycerides, cardiac risk indices. However, the co-administration of MSBECK caused a significant (p<0.05) dose-dependent improvement in blood cells and restored total serum cholesterol, triglycerides, LDL-cholesterol and cardiac risk indices to normal ranges. Conclusion: The study showed that methanolic stem bark extract of Commiphora kerstingii protected against a reduction i | en_US |
| dc.description.sponsorship | self | en_US |
| dc.identifier.issn | 1727-3048 | |
| dc.identifier.uri | http://dspace.run.edu.ng:8080/jspui/handle/123456789/851 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartofseries | ;1 | |
| dc.title | Protective Effects of Methanolic Stem Bark Extract of Commiphora kerstingii Engl. on Pancytopenia and Hyperlipidemia Induced with CdCl2 in Male Wistar Rats | en_US |
| dc.type | Article | en_US |