Assessment of the Antidiabetic Potential of the Ethanolic Extract of Date Palm (Phoenix Dactylifera) Seed in Alloxan-Induced Diabetic Rats.

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dc.contributor.authorAbiola, Temitope
dc.date.accessioned2022-04-27T09:44:57Z
dc.date.available2022-04-27T09:44:57Z
dc.date.issued2018-01-19
dc.description.abstractBackground: Reports exist of the allopathic use of dates as a hypoglycemic, antioxidant and anti-diabetic agent. Date palm seed have also been found to be of nutritional and medicinal value Aim: this study was aimed at evaluating the anti-diabetic potential of the ethanolic extract of date palm seed inalloxan-induced diabetic rats. Methodology: Proximate composition of date palm seed was determined using standard methods. Ethanolicextract of date palm seed was prepared by crude extraction protocol. The total flavonoids, phenolic contents andtotal antioxidant capacity of the seed extract was determined. Also, the scavenging activity of the extract using 1, 1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO) and the reducing power was also evaluated. Thirty wistar ratswere randomly divided into five groups of six rats each. Group A was the control group, group B received date palmseed extract only (200 mg/kg bw) i.p, group C, D and E were the diabetic groups that received alloxan (150 mg/kgbw) intra peritoneally; group C was the diabetic control group, group D and group E were treated with glibenclamide(5 mg/kg bw) and date palm seed extract (400 mg/kg bw) intraperitoneally for fourteen days. At the end of the experiment, the lipid profile parameters (HDL, LDL, VLDL, cholesterol and triglyceride) levels were determined fromserum samples of the animals. Levels of glucose and antioxidant parameters (SOD, CAT, GSH and MDA) were also analysed from the serum samples of the experimental animals. Results: Results of proximate analysis revealed fiber to be highest (61.75%), carbohydrate (20.95%), fat(8.55%), moisture (3.40%), ash (2.79%) and protein (2.63%). The total flavonoid and phenolic content of date palmseed was found to be 45.28 ± 0.32 mg/100 g and 28.22 ± 0.43 mg/100 g respectively while the total antioxidantcapacity was 30.11 ± 0.21 mg/100 g. There was a significant (P<0.05) decrease in the levels of LDL, VLDL,cholesterol, triglyceride and blood glucose with no significant (P>0.05) increase in the HDL of the diabetic treatedgroups as compared to the diabetic control group. A significant (P<0.05) increase was observed in the SOD, CAT,GSH levels while there was a significant (P<0.05) decrease in the MDA level of the diabetic group treated with datepalm seed extract as compared to the diabetic control group. Conclusion: This study suggests the anti-diabetic potential of date palm seed extract which might be due to itshypolipidemic, hypoglycemic and antioxidant propertiesen_US
dc.identifier.citationAbiola T, Dibie DC, Akinwale OJ, Shomuyiwa OA (2018) Assessment of the Antidiabetic Potential of the Ethanolic Extract of Date Palm(Phoenix Dactylifera) Seed in Alloxan-Induced Diabetic Rats. J Diabetes Metab 9: 784. doi:10.4172/2155-6156.1000784en_US
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/2451
dc.language.isoenen_US
dc.publisherJournal of Diabetes and Metabolismen_US
dc.subjectPhoenix dactyliferaen_US
dc.subjectAlloxanen_US
dc.subjectAnti-diabeticen_US
dc.subjectAntioxidanten_US
dc.subjectLipid profileen_US
dc.titleAssessment of the Antidiabetic Potential of the Ethanolic Extract of Date Palm (Phoenix Dactylifera) Seed in Alloxan-Induced Diabetic Rats.en_US
dc.typeArticleen_US
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