Effect of Crude and Decaffeinated Extracts of Cola nitida Seeds on Male Reproductive System in Swiss Albino Rats
Loading...
Files
Date
2016-10-03
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Caffeine is present in kola nut and
xanthine stimulants which are used as a
psychoactive drug. Therefore, the effect of kola
nut (Cola nitida) extract was carried out on male
reproductive system in male albino rats. Aim and
Objectives: This study was aimed to determine the
effect of oral administration of Crude Extract of
Kola (CEK) and Decaffeinated Extract of Kola
(DEK) on the reproductive function in male Swiss
albino rats. Material and Methods: Twenty-four
adult male albino rats were used for this study,
they were assigned into three groups consisting
eight rats each. Group 1 (control group) received
(8mg/kgbw) of distilled water for six weeks,
Group 2 (crude extract group) received (8mg/kg
bw) of CEK for six weeks, and Group 3
(decaffeinated extract group) was treated with
(8mg/kg bw) of DEK for six weeks. Result: CEK
showed no significant decrease in the body weight
and sperm count when compared with the control
group. No significant difference in seminal
parameter (motility, morphology, viability), organ
weight (testis) and hormonal assay (testosterone,
follicle stimulating hormone, luteinizing
hormone) when compared with the control group.
DEK showed no significant different in body
weight, hormonal assay (testosterone and follicle
stimulating hormone, seminal parameter (sperm
viability, count, morphology and motility), organ weight (testes and epipidymis) of the animal;
however significant increase was observed in
luteinizing hormone when compared with control
group. Asignificant increase in the sperm count of
decaffeinated group was observed (p = 0.02) when
compared with crude group. Conclusion: This
study indicates that CEK and DEK have little
effects on male reproductive system.