Anti-diabetic Effect of Combined Treatment with Aloe vera gel and Metformin on Alloxan-Induced Diabetic Rats
Loading...
Date
2018
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Ayurvedic and Herbal Medicine
Abstract
Aim: The present study investigated the effects of intensive glucose regulation with combined treatment of Aloe vera
gel (a herbal agent) and Metformin in an alloxan-induced diabetic rat model. Methods: Forty rats were assigned to the
following groups and treated for 21 days: Group 1 (normal untreated control), Group 2 (untreated diabetic rats, DR),
Group 3 (DR + 300 mg/kg PE of Aloe vera ), Group 4 (DR + 2 mg/kg Metformin) and Group 5 (DR + 300 mg/kg PE of Aloe
vera + 2 mg/kg Metformin). The effect of the treatments on fasting blood glucose (FBG) level, lipid profile, renal
function, atherogenic index, pancreas and kidney histopathologies were assessed. Results: FBG level in Group 5 rats
decreased by 28.4, 38.0 and 69.0% at Day 7, 14 and 21, respectively. Hyperlipidaemia, high atherogenic index,
increased plasma creatinine and urea levels observed in the diabetic rats were ameliorated by the single and combined
treatments with Aloe vera and Metformin. Reduced level of HDL-cholesterol in the untreated diabetic rats significantly
improved by 160.0, 89.8 and 178.7% respectively in Group 3, 4 and 5 animals. The pancreas and kidney
histopathologies indicated signs of recovery in Group 5 rats unlike those of Group 2 that had evidence of necrotic cells
in both the acini and islet in pancreas and total glomeruli erosion in kidney. Conclusion: Aloe vera in combination with
Metformin for treatment of diabetic patients could avert diabetes-associated dyslipidaemia, improve cellular integrity
and increase, thereby preventing patients from risk of cardiovascular diseases and kidney failure
Description
Keywords
Diabetes mellitus, Aloe vera, Metformin, Hyperlipidaemia, Hyperglycaemia, Renal failure