Dietary Selenium or Zinc Supplementation Restores Brain Lipid Composition and Membrane Fluidity in Protein-Undernourished Rats

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dc.contributor.authorAdebayo, Olusegun
dc.date.accessioned2022-02-18T08:14:59Z
dc.date.available2022-02-18T08:14:59Z
dc.date.issued2016
dc.description.abstractStudies have shown that protein undernutrition (PU) modifies the membrane lipid composition in the intestine and liver, as well as in plasma and other areas. However, there is limited information on the effect of PU on synaptosomal membrane lipid composition and fluidity and the protective role of selenium (Se) and zinc (Zn), which is a major focus of the present study. For 10 weeks, rats were fed diets containing 16% casein, which constituted the adequate protein diet, or 5% casein, representing the PU diet. The animals were supplemented with Se and Zn at a concentration of 0.15 and 227 mg L-1, respectively, in drinking water for 3 weeks. The results showed a significant increase in total lipids, glycolipids, triglycerides, cholesterol, and the cholesterol/phospholipid (Chol/PL) ratio, and a significant reduction in phospholipids and membrane fluidity. Se and Zn supplementation to PU rats, however, significantly lowered total lipids, glycolipids, triglycerides, cholesterol, and the Chol/PL ratio, while phospholipids and membrane fluidity were significantly restored. It is concluded that a perturbed lipid composition induced by PU affects the membrane structure and fluidity, which in turn influences membrane functions. The study suggests that Se and Zn supplementation might be beneficial in restoring the lipid dyshomeostasis associated with PU.en_US
dc.description.sponsorshipTWAS and RTFDCSen_US
dc.identifier.citation1en_US
dc.identifier.otherDOI: 10.1159/000462971
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/1310
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofseries38(6);397-406
dc.subjectBrainen_US
dc.subjectLipiden_US
dc.subjectMembraneen_US
dc.subjectNutritionen_US
dc.subjectTrace elementen_US
dc.titleDietary Selenium or Zinc Supplementation Restores Brain Lipid Composition and Membrane Fluidity in Protein-Undernourished Ratsen_US
dc.typeArticleen_US
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The study suggests that Se and Zn supplementation might be beneficial in restoring the lipid dyshomeostasis associated with protein-undernutrition.
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