D-Ribose-L-Cysteine Prevents Oxidative Stress and Cardiometabolic Syndrome in High Fructose High Fat Diet Fed Rats

dc.contributor.author	Ojetola, Abodunrin
dc.date.accessioned	2022-04-29T16:10:26Z
dc.date.available	2022-04-29T16:10:26Z
dc.date.issued	2021-08-13
dc.description.abstract	Cardiometabolic syndrome has been linked with dietary modification. Therefore, we investigated the effects of D-ribose-L-cysteine (DRLC) in rats fed with high fructose high fat (HFHF) diet. Twenty rats (n = 5), divided into 4 groups were concurrently exposed to HFHF and/or DRLC (250 mg/kg, p.o) during the 8 weeks study. The result showed that compared to control group, HFHF group had significant impairment in lipid and glucose homeo- stasis, increased cardiac xanthine oxidase, systolic blood pressure, heart rate, %body weight change and fluid intake. Also, there were significant reductions in HDL-C, cardiac (GPX, NO&GGT), feed intake and relative heart weight in the latter, relative to the former. However, there were no significant differences in most of the observed physical and biochemical changes in HFHF + DRLC group compared to control. DRLC alone did not disrupt the level of biomarkers. Conclusively, DRLC prevented the manifestation of oxidative stress and cardiometabolic syndrome in HFHF-diet fed rats.	en_US
dc.identifier.uri	http://dspace.run.edu.ng:8080/jspui/handle/123456789/2545
dc.language.iso	en	en_US
dc.publisher	Elsevier	en_US
dc.title	D-Ribose-L-Cysteine Prevents Oxidative Stress and Cardiometabolic Syndrome in High Fructose High Fat Diet Fed Rats	en_US
dc.type	Article	en_US

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