Behavioural Cellular and Neurochemical Alterations in Rat Prefrontal Cortex and Hippocampus Exposed to Tigernut (Cyperus Esculentus) Treatment
| dc.contributor.author | Arogundade, Tolulope | |
| dc.date.accessioned | 2022-05-09T09:49:16Z | |
| dc.date.available | 2022-05-09T09:49:16Z | |
| dc.date.issued | 2018-12-18 | |
| dc.description.abstract | Investigating substances of plant origin for therapeutic advantages over subcellular mechanisms underlying a number of physiological dysfunctions could foster the development of potent therapeutic strategies for the treatment of these dysfunctions. We explored the effects of Tigernut (Cyperus esculentus) consumption on neurochemical, behavioural and cellular parameters in prefrontal and hippocampal regions of rat brain. Twenty-four (24) adult male Wistar rats with an average weight of 180g±10g were randomly split into 4 (A-D) groups (n=6); Groups A – C received 10mg/kg, 20mg/kg, and 30mg/kg bodyweight of Tigernut extract respectively for 14days, while Group D served as the control receiving distilled water. Animals were sacrificed 24hours after the last day of administration. Behavioural assessment of the cortico-hippocampal neural circuitry in Tigernut–treated rats showed increased memory function compared to control, evidenced by an increase in correct spontaneous alternation in the Tigernut-treated groups. Neural malondialdehyde (MDA) levels was significantly reduced in treated rats in order of increasing dose, while the concentrations of catalase (CAT) and superoxide dismutase (SOD) were significantly increased. These observations hinted at the antioxidant properties of Tigernut. Subsequent analysis of the total antioxidant capacity in animals revealed elevated antioxidant levels significantly in the 10mg/kg and 20mg/kg groups. Furthermore, the microarchitecture of the prefrontal cortex and hippocampus appeared normal and well-structured. Our results show that Tigernut has neurotherapeutic and antioxidant properties at moderate doses and can therefore, be used to augment the endogenous production of antioxidants in the different brain regions | en_US |
| dc.identifier.citation | Arogundade TT, Yawson EO, Gbadamosi IT, Abayomi AT, Tokunbo OS, Lambe ET, Bamisi OD, Alabi AS (2018). Behavioural cellular and neurochemical alterations in rat prefrontal cortex and hippocampus exposed to tigernut (Cyperus esculentus) treatment. Journal of Environmental Toxicology and Public Health 3: 38-46. http://doi.org/10.5281/zenodo.2392222 | en_US |
| dc.identifier.issn | 2476-7948 | |
| dc.identifier.uri | http://dspace.run.edu.ng:8080/jspui/handle/123456789/2863 | |
| dc.language.iso | en | en_US |
| dc.publisher | Journal of Environmental Toxicology and Public Health | en_US |
| dc.subject | Tigernut, | en_US |
| dc.subject | Prefrontal cortex | en_US |
| dc.subject | Hippocampus | en_US |
| dc.subject | Biochemical redox | en_US |
| dc.subject | Wistar rat | en_US |
| dc.title | Behavioural Cellular and Neurochemical Alterations in Rat Prefrontal Cortex and Hippocampus Exposed to Tigernut (Cyperus Esculentus) Treatment | en_US |
| dc.type | Article | en_US |