Ocimum gratissimum Ameliorates Gentamicin-Induced Kidney Injury but Decreases Creatinine Clearance Following Sub-Chronic Administration in Rats
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Date
2017-01-07
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SAGE
Abstract
The effects of aqueous extract of Ocimum gratissimum leaf (AOGL) on the renal function of rats with gentamicin-induced
nephrotoxicity were investigated. This study involved the use of forty five (45) adult male Wistar rats (housed in separate
metabolic cages) such that graded doses of OAGL were administered to the experimental groups (p.o.) for 28 days after exposure
to gentamicin toxicity (100 mg/kg i.p.) for 1 week. At the end of the study, comparisons of some indices of renal function as well as
antioxidant status (GSH and TBARS) were made between the control, toxic and AOGL-treated groups at P < 0.05. The result
showed that gentamicin treatment caused significant increase (P < .05) in urine output, urea, creatinine, total protein, relative
kidney weight, and TBARS, as well as significant decrease (P < .05) in urine creatinine and GSH levels. Post-treatment with graded
doses of AOGL caused significant increase in food consumption, GSH, urine, and plasma creatinine, as well as significant decrease
(P < .05) in relative kidney weight, TBARS, and urine total protein. There was an appreciable difference in the kidney histology of
the AOGL-treated groups when compared with the toxic control. Hence, the extract has therapeutic potential in the man agement of gentamicin-induced kidney injury, although a risk profile of renal dysfunction is not unlikely from 28 days of admin istration as evident by the decrease in creatinine clearance