Microstructural Effects of Celosia trigyna Leave Extracts on the Liver and Ileum in Ethanol-induced Toxicity in Adult Wistar Rats
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Date
2020-03-15
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Science Alert
Abstract
Celosia trigyna is from the family Amaranthaceae and highly consumed by human beings and animals. The leaves are rich in antioxidants and used medicinally to treat wounds, diarrhea and mouth ulcers. The aim of this study was to evaluate the healing potential of Celosia trigyina leave extracts on the liver and ileum in ethanol-induced toxicity in adult Wistar rats. Materials and Methods: Thirty adult wistar rats were procured, acclimatized and randomly divided into 6 groups of 5 animals each. Rats in groups 2-6 were administered with 5 mL kg–1 of 90% ethanol while animals in group 1 were administered with equivalent volume of distilled water. After 24 h, animals in groups 3-6 were administered with leave extracts of Celosia trigyna (methanol, dichloromethane, ethyl acetate and hexane, respectively). The therapies went on repeatedly for 14 days in all animal groups. Twenty four h after the last administration, the liver and ileum were excised and fixed in 10% formol saline for histopathological analysis. Results: The result showed a significant decrease (p<0.05) in the weight difference of animals in group 2 when compared to the Celosia trigyna treated groups. Furthermore, the histopathological evaluation showed a remarkable recovery of the necrotized hepatocytes by the leave extracts of Celosia trigyna with the dichloromethane and hexane extracts having better remediation against ethanol induced toxicity in both the liver and ileum than the methanol and ethyl acetate extracts. Conclusion: In conclusion, the leave extracts of Celosia trigyna showed promising protection of the liver and ileum against ethanol-induced toxicity in adult Wistar rats. This protection may be due to the antioxidant potential of Celosia trigyna.
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Liver, Ileum, Toxicity, Histopathology, Ethanol, Antioxidants
Citation
David Adesanya Ofusori, Adebimpe Esther Ofusori, Paul Olugbemiga Awoniran, Gracious Oluwamayowa Oke, Taiwo Adekemi Abayomi and Tolulope Adefola Edward, 2020. Microstructural Effects of Celosia trigyna Leave Extracts on the Liver and Ileum in Ethanol-induced Toxicity in Adult Wistar Rats. Research Journal of Medicinal Plants, 14: 64-71.