Histomorphological and Redox Delineations in the Testis and Epididymis of Albino Rats Fed with Green-Synthesized Cellulose

dc.contributor.authorAdebayo, Olusegun
dc.date.accessioned2022-05-04T13:24:55Z
dc.date.available2022-05-04T13:24:55Z
dc.date.issued2020-08-25
dc.description.abstractIt has also become increasingly necessary to diversify the production of cellulose for biomedical applications. In this study, cellulose-green-synthesized from Sesamum indicum (GSC)—was administered orally to rats for 14 days as follows: control, 100, 200 and 400 mg/kg GSC. The impact of GSC on the antioxidant status and histomorphology of the testes and epididymis were studied. GSC had no effects on organ weights and organosomatic indices. In the testes, GSC caused nonsignificant changes in superoxide dismutase, catalase, reduced glutathione and nitric oxide levels, whereas it significantly decreased glutathione peroxidase and malondialdehyde levels. In the epididymis, GSC significantly decreased superoxide dismutase and nitric oxide levels, but caused a significant increase in glutathione peroxidase and reduced glutathione levels. Furthermore, at ×200 magnification, testicular morphology appeared normal at all doses, however, extravasation of the germinal epithelium of the epididymis was observed at doses of 200 and 400 mg/kg GSC. Conversely, at ×400 magnification, spermatogenic arrest (testes) and chromatolytic alterations (epididymis) were observed at the higher doses (200 and 400 mg/kg GSC). This study reports on the effect of green-synthesized cellulose on testicular and epididymal histology and redox status and further extends the frontiers of research on cellulose.en_US
dc.identifier.issndoi:10.3390/biology9090246
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/2613
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofseries9;246
dc.subjectGreen-synthesized celluloseen_US
dc.subjectRedox statusen_US
dc.subjectHistomorphologyen_US
dc.subjectTestesen_US
dc.subjectEpididymisen_US
dc.titleHistomorphological and Redox Delineations in the Testis and Epididymis of Albino Rats Fed with Green-Synthesized Celluloseen_US
dc.typeArticleen_US
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