Eco-friendly synthesis and assessment of chrysin – primed zinc ferrite nanoparticles against vinyl chloride and 2-acetylaminofluorene model of hepatorenal injury in rats
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Date
2024
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Elsevier
Abstract
Co-exposure to environmental toxicants is becoming an emerging problem globally. This study investigated the
potential of chrysin-primed zinc-ferrite nanoparticles (ZnFe2O4@Chrysin) to counteract oxidative stress and
inflammation in vinyl chloride (VC) and 2-acetylaminofluorene (2-AAF) induced liver and kidney toxicities in
male Wistar rats. ZnFe2O4@Chrysin was identified using x-ray diffraction, thermogravimetric analysis, Fourier
Transform Infrared spectroscopy, scanning and transmission electron micrographs. Molecular orbital distribu
tions in chrysin were determined using Density Functional Theorem analyses. Forty –two rats were placed in six
groups of seven animals each, and orally administered with ZnFe2O4@Chrysin (10, 20, 50 mg/kg), VC (50 mg/
kg) and 2-AAF (30 mg/kg) over a period of 28 days. Liver and kidney function, lipid profile, oxidative stress,
inflammation, endocrine and cancer parameters were evaluated. Treatment with ZnFe2O4@Chrysin ameliorated
the VC +2-AAF induced elevations in alanine aminotransferase, aspartate aminotransferase, alkaline phos
phatase, triglyceride, urea, uric acid, and sodium and potassium levels. VC +2-AAF also caused significant el
evations in superoxide dismutase, malondialdehyde, nitric oxide, myeloperoxidase levels which were restored by
ZnFe2O4@Chrysin. Elevated levels of alpha fetoprotein, C-reactive protein (CRP) and thyroid stimulating hor
mone in VC +2-AAF treated rats were significantly reversed by ZnFe2O4@Chrysin. ZnFe2O4@Chrysin also
restored the histoarchitecture of the kidney and liver of rats exposed to VC +2-AAF. This study suggests that
ZnFe2O4@Chrysin offered protection against VC and 2-AAF induced alterations in biochemical indices of rats via
anti-inflammatory and antioxidant mechanisms.
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Adesina, A. F., Adewuyi, A., & Otuechere, C. A. (2024). Eco-friendly synthesis and assessment of chrysin–primed zinc ferrite nanoparticles against vinyl chloride and 2-acetylaminofluorene model of hepatorenal injury in rats. Results in Chemistry, 7, 101524.