Metabolome Modulatory Effects of Kigelia Africana (Lam.) Benth Fruit Extracts on Oxidative Stress, Hyperlipidemic Biomarkers in STZ-induced Diabetic Rats and Antidiabetic Effects in 3T3 L1 Adipocytes

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dc.contributor.authorJolayemi, Kehinde
dc.date.accessioned2022-05-09T12:46:52Z
dc.date.available2022-05-09T12:46:52Z
dc.date.issued2020-06-29
dc.description.abstractObjectives The management of diabetes is considered a global problem, and a cure is yet to be discovered. This study investigated the modulatory effect of Kigelia africana fruit on oxidative stress and hyperlipidaemic biomarkers in STZinduced diabetic rats, profiled phytoconstituents using GC-TOF-MS and evaluated antidiabetic effects on 3T3 L1 adipocytes. Methods Thirty male Wistar rats (120–150 g) were divided into six groups (n = 5). Diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg) and treated with 100, 200 and 400 of hexane fraction of KA for 28 days. Immunohistochemical evaluation was carried out using avidin-biotin immunoperoxidase (ABI) method. Catalase and SOD activities as well as the levels of total protein, albumin, bilirubin, triglyceride, cholesterol, and high-density lipoprotein were measured. Key findings The expressions of oxidative stress and hyperlipidaemic biomarkers alongside fasting blood glucose concentrations were remarkedly decreased in KAtreated diabetic rats. Moreover, there was a significant increase in endocrine cell distribution, area covered with increase in b-cell mass, composition and morphology of KA-treated animals. Additionally, there was constant up-regulation in 3T3 L1 adipocytes due to the presence of phytoconstituents. Conclusion Kigelia africana fruit can act as a modulatory agent due to its ameliorative effects against oxidative stressen_US
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/2917
dc.language.isoenen_US
dc.publisherElseveir (Scopus Indexed)en_US
dc.subjectantioxidant enzymesen_US
dc.subjectavidin-biotin immunoperoxidaseen_US
dc.subjectDiabetes mellitusen_US
dc.subjectGC-TOF-MSen_US
dc.subjectKigelia africanaen_US
dc.titleMetabolome Modulatory Effects of Kigelia Africana (Lam.) Benth Fruit Extracts on Oxidative Stress, Hyperlipidemic Biomarkers in STZ-induced Diabetic Rats and Antidiabetic Effects in 3T3 L1 Adipocytesen_US
dc.typeArticleen_US
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