Metformin Potentiates the Antidiabetic Properties of Annona muricata and Tapinanthus globiferus Leaf Extracts in Diabetic Rats
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Date
2021
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Pharmacognosy Journal
Abstract
Background: There is paucity of experimental evidence on the complementary use of standard
anti-diabetic drugs with herbal formulations. Materials and Methods: In this study, extracts of
Annona muricata (AME) and Tapinanthus globiferus (TGE) were administered with metformin
to diabetic rats in order to study the potential complementary effects. Diabetes was induced
by a single intraperitoneal (i.p) injection of alloxan (150 mg/kg BW). AME and TGE (200 mg/
kg BW each) and Metformin (100 mg/kg BW) was administered to diabetic rats orally for 21
days. At the end of the study, rats were sacrificed; blood was collected for assessment of lipid
profile and kidney function. Results: Treatment of diabetic rats with AME and TGE caused a
significant decrease (p < 0.05) in the concentrations of total cholesterol (TC), triglyceride (TG)
and Coronary Risk Index (CRI) with a concomitant increase in High Density Lipoprotein (HDL).
Similarly, urea and creatinine concentration decreased in diabetic rats administered plant
extracts. Co-administration of the plant extracts with metformin significantly improved lipid
profiles and kidney function relative to rats administered metformin alone. Co-administration
of AME and TGE extracts with metformin produced significant improvement in biochemical
indices of diabetic rats. Conclusion: The results suggest potential synergistic interaction
between the plant extracts and metformin. Furthermore, this work provides scientific
support for the concomitant use of the plants used in the study with orthodox drugs for the
management of diabetes.
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Keywords
Annona muricata, Diabetes, Drug interaction, Tapinanthus globiferus