Alteration of Early-Phase Piperaquine Disposition by Concurrent Administration of Clarithromycin in Healthy Volunteers

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dc.contributor.authorAdemisoye A.I.
dc.date.accessioned2025-06-05T13:11:55Z
dc.date.available2025-06-05T13:11:55Z
dc.date.issued2024
dc.description.abstractMalaria and Helicobacter pylori infections are some of the most prevalent infectious diseases causing thousands of deaths worldwide. Concurrent infections can exacerbate co-morbidities or make worse the management of malaria. Drug-drug interactions arising from activities of CYP450 during concurrent management of the co-infections could worsen management challenges and therapeutic outcomes. Fifteen healthy volunteers were administered single oral dose of P-Alaxin© consisting piperaquine (960 mg) and dihydroartemisinin (240 mg). Following a five-month wash out period, clarithromycin (500 mg) was administered twice daily for five days. A single dose of P-Alaxin© was administered on the 3rd day. Blood samples were collected within 48 hours and analyzed for plasma levels of the administered drugs using RP-HPLC methods. The Tmax was 5.2±2.11 h vs 5.47±2.56 h and did not vary significantly p>0.05. However, Cmax and AUC0-48, of piperaquine when concurrently administered with clarithromycin increased significantly (179.41±56.35 ng/ml vs 478.99 ± 148.86 ng/ml; 37,644.56 ± 16.716.95 vs 104,098.47 ± 53.311.57 ng/ml*h respectively (p<0.05).quine during concurrent administration could be a pointer to major drug interactions that may manifest during full course of management of the concurrent infections. pharmacokinetic parameters in the early phase metabolism of piperaquine during concurrent administration cou
dc.identifier.uri10.23880/apct-16000250
dc.identifier.urihttps://repository.run.edu.ng/handle/123456789/5263
dc.language.isoen
dc.publisherAdvances in Pharmacology and Clinical Trials
dc.relation.ispartofseries9; 4
dc.titleAlteration of Early-Phase Piperaquine Disposition by Concurrent Administration of Clarithromycin in Healthy Volunteers
dc.typeArticle
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