Trévo abrogates Lead Acetate Neurotoxicity in Male Wistar Rats viz Antiamyloidogenesis, Antiglutaminergic, and Anticholinesterase Activities
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Date
2022
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Publisher
Annals of Neurosciences
Abstract
Background: Exposure to lead has been linked to biochemical changes similar to those patients suffering
from Alzheimer’s disease. Trévo is a phytonutrient-rich product with antiaging and antioxidant
properties.
Purpose: To investigate the neuroprotective activity of trévo against lead-induced biochemical changes
in male Wistar rats.
Methods: The study involves 35 animals that were randomly divided into five groups of seven rats each.
Group I (Control): Orally administered distilled water; Group II (Induced): Administered 15 mg/kg of lead
acetate (PbA) intraperitoneally; Group III (Treatment group): Orally administered 2 mL/kg of trévo for
two days before co-administration with PbA for 12 consecutive days; Group IV (Treatment group): Orally
administered 5 mL/kg of trévo for two days prior to coadministration with PbA for 12 consecutive days;
Group V: Orally administered 5 mL/kg of trévo for 14 consecutive days. Animals were anesthetized with
diether and the brain excised and processed for the following biochemical assays: Malonedialdehyde
(MDA), glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione-Stransferase (GT),
acetylcholinesterase (AChE), beta-amyloid, glutamate, Na+/K+ ATPase, and glutamate dehydrogenase
(GD).
Results: PbA caused significant oxidative stress (increased MDA concentration, decreased GSH
concentration, suppressed the activity of CAT, SOD), decreased GT activity, increased activity of AChE,
increased the concentration of beta-amyloid, and caused glutamate excitotoxicity (increased
concentration of glutamate, decreased activity of Na+/K+ ATPase, and GD) in rat brains. Treatment with
trévo at the two different doses significantly prevented oxidative damage, beta-amyloid aggregation,
glutamate excitotoxicity, and acetylcholine breakdown induced by lead acetate.
Conclusion: Our findings added to the reported pharmacological activity of trévo and supported the
antiaging potential of trévo
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Keywords
Phytomedicine, Heavy metals, Neurotoxicity, Acetylcholine, Caspases, Beta-amyloid, Antioxidant