High Cross Reactivity of Human T Cell Responses between Lassa Virus Lineages.

Simple item page
dc.contributor.authorFolarin, Onikepe
dc.date.accessioned2022-05-09T07:50:38Z
dc.date.available2022-05-09T07:50:38Z
dc.date.issued2020
dc.description.abstractLassa virus infects hundreds of thousands of people each year across rural West Africa, resulting in a high number of cases of Lassa fever (LF), a febrile disease associated with high morbidity and significant mortality. The lack of approved treatments or interventions underscores the need for an effective vaccine. At least four viral lineages circulate in defined regions throughout West Africa with substantial interlineage nucleotide and amino acid diversity. An effective vaccine should be designed to elicit Lassa virus specific humoral and cell mediated immunity across all lineages. Most current vaccine candidates use only lineage IV antigens encoded by Lassa viruses circulating around Sierra Leone, Liberia, and Guinea but not Nigeria where lineages I-III are found. As previous infection is known to protect against disease from subsequent exposure, we sought to determine whether LF survivors from Nigeria and Sierra Leone harbor memory T cells that respond to lineage IV antigens. Our results indicate a high degree of cross-reactivity of CD8+ T cells from Nigerian LF survivors to lineage IV antigens. In addition, we identified regions within the Lassa virus glycoprotein complex and nucleoprotein that contributed to these responses while T cell epitopes were not widely conserved across our study group. These data are important for current efforts to design effective and efficient vaccine candidates that can elicit protective immunity across all Lassa virus lineagesen_US
dc.identifier.citationSullivan BM, Sakabe S, Hartnett JN, Ngo N, Goba A, Momoh M, et al. (2020) High crossreactivity of human T cell responses between Lassa virus lineages. PLoS Pathog 16(3): e1008352. https://doi.org/10.1371/journal. ppat.1008352en_US
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/2811
dc.language.isoenen_US
dc.publisherPLoS Pathogenen_US
dc.titleHigh Cross Reactivity of Human T Cell Responses between Lassa Virus Lineages.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2_2020_Sullivan_High cross reactivity of human T cell responses between Lassa virus lineages. .pdf
Size:
2.64 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Department of Biological Sciences