Atherogenic Index and Lipid Profiles in Albino Rats Fed with Surface Modified Hibiscus sabdariffa Cellulose
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Date
2021-11
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Publisher
Elsevier
Abstract
Despite the several applications of modified cellulose, there is limited information on their
safety, and antidyslipidemic functions, which are the focus of this study. To address this,
cellulose isolated from Hibiscus sabdariffa cellulose was surface modified using nitrilotri-
acetic acid to produce nitrilotriacetic acid modified Hibiscus sabdariffa cellulose (HSNT). It
was characterized using Fourier transformed infrared spectroscopy (FTIR), X-ray diffraction
(XRD), thermogravimetric (TGA) analysis, scanning electron microscopy (SEM) and carbon,
hydrogen, nitrogen, sulfur/oxygen (CHNS/O) analyzer. The study further investigated the
safety of HSNT at the doses of 50, 100, and 150 mg kg−1 body weight in albino rats after
a 7-day uninterrupted oral gavage. Histology of cardiac and hepatic tissues was observed,
in addition to estimation of clinico-biochemical parameters such as atherogenic index of
plasma (AIP), Castelli’s risk index (CRI-1), total cholesterol, high-density lipoprotein choles-
terol (HDL-C), triglyceride (TG), albumin (ALB), aspartate aminotransferase (AST) and ala-
nine aminotransferase (ALT). FTIR revealed peaks corresponding to the synthesis of HSNT,
while XRD showed HSNT to have a crystallinity index of 53.20% with a type I cellulose
crystal. HSNT had no significant effect on the absolute heart and liver weights, heart and
liver organo-somatic indices, TG, AST, and ALB. Exposure to HSNT-50 caused a significant
decrease in AIP levels. However, administration of HSNT-100 and 150 significantly reduced
ALT, total cholesterol, and CRI-1 levels but caused a significant elevation in HDL-C lev-
els. Cardiac histology revealed mild inflammatory and fatty infiltration of the myocardium,
while the significant indications of the hepatic morphology included congestion of vessels
and mild focal periportal infiltration at the HSNT-100 and HSNT-150 doses. Our preliminary
data seem to indicate the potential of HSNT modification to resolve blood lipid abnormal-
ities and make a case for an expanded study on its cardio-hepatic effects as well as study
to understand the causes of congestion in hepatic vessels
Description
Keywords
Atherogenic index, Lipid profiles
Citation
Adewuyi A, Otuechere CA, Adebayo OL, Oyeka M, Adewole C (2021). Atherogenic index and lipid profiles in albino rats fed with surface modified Hibiscus sabdariffa cellulose, Scientific African doi:https://doi.org/10.1016/j.sciaf.2021.