Impact of an Acylanilide Herbicide Propanil on Biochemical Indices in Kidney of Diabetic Rats
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2019-03-14
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Asian Journal of Biological Sciences
Abstract
Background and Objective: Propanil (PRO) is an acylanilide herbicide used to control barnyard grass and broad leaf weeds. This study evaluated the impact of PRO in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Diabetes was induced in rats by a single injection of STZ (60 mg kgG1 intraperitoneal, i.p.). The PRO was administered at the dose of 200 mg kgG1 (i.p. for 7 days), to both normal and diabetic rats. Results: The plasma levels of triglyceride, aspartate aminotransferase, creatinine and renal malondialdehyde level (an index of lipid peroxidation) were significantly increased in diabetic rats. In addition, the levels of high density lipoprotein-cholesterol, superoxide dismutase were depressed in the STZ-treated rats compared to the control group. The co-exposure of PRO increased absolute organ weight, catalase, glutathione peroxidase and malondialdehyde levels. Conclusion: Taken together, exposure to PRO exacerbated oxidative stress in renal tissue of diabetic rats.
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ChiagoziemAnariochiOtuechere,FemiAyoadeandOladejiJohnArogundade,2019.Impactofanacylanilideherbicidepropanilonbiochemical indices in kidney of diabetic rats. Asian J. Biol. Sci., 12: 210-216.