Pterocarpus mildbraedii (Harms) Extract Resolves Propanil-Induced Hepatic Injury via Repression of Inflammatory Stress Responses in Wistar Rats
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Date
2020-09-17
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Publisher
Wiley
Abstract
Pterocarpus mildbraedii (PME) is a green leafy vegetable from the Papilionaceae
family. This study evaluated the anti-inflammatory activity of PME in Wistar rats
exposed to experimental hepatotoxicity using propanil (PRP), a post-emergent herbicide.
Animals were grouped as control, PRP, PME, and PME + PRP. After 7 days, the
levels of stress-activated protein kinases/c-Jun N-terminal kinase (SAPK/JNK), p38
mitogen-activated protein kinase (p38 MAPK), and signal transducer and activator
of transcription (STAT-3) were measured in rat liver. Furthermore, myeloperoxidase
(MPO) and nitric oxide (NO) levels, as well as protein expressions of nuclear factor-κB
(NF-κB p65), inducible nitric oxide synthase (iNOS), and cyclo-oxygenase-2 (COX-2)
were determined. Compared with PRP-treated rats, PME significantly reduced the
hepatic MPO and NO levels. PME also diminished NFκB, iNOS, and COX-2 protein
expressions in PRP-treated rats. This study showed that Pterocarpus mildbraedii
leaves produce active principles with relevant anti-inflammatory potential.
Practical applications
Previous studies have shown that bioactive principles contained in medicinal plants
can offer protection against chemically induced inflammation. Pterocarpus mildbraedii
leaves, with rich content of polyphenols, flavonoids, and essential fatty acids,
could be exploited as a therapeutic agent against pesticide-induced oxidative stress
and inflammation. This current study has also shown that the potential of PME as a
functional food is boosted by the presence of α-linolenic acid, an omega-3-fatty acid
known to possess anti-inflammatory activity. Here, we elucidated the cellular mechanisms
of the anti-inflammatory action of PME.
Description
Keywords
Propanil, Transcription factors
Citation
Pterocarpus mildbraedii (Harms) extract resolves propanil-induced hepatic injury via repression of inflammatory stress responses in Wistar rats. Journal of Food Biochemistry: e13506. https://doi.org/10.1111/jfbc.13506.