Biochemical Changes in the Liver and the Pancreas of Well-fed and Protein Undernourished Rats Following Fluoride Administration

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dc.contributor.authorAdebayo, Olusegun
dc.date.accessioned2022-02-08T11:03:57Z
dc.date.available2022-02-08T11:03:57Z
dc.date.issued2012
dc.description.abstractThe biochemical changes in the liver and the pancreas after exposure to 100 ppm fluoride (NaF) in drinking water for one week on Protein Undernourished (PU) and Well-Fed (WF) rats were investigated. The results show that PU induced significant reductions (p<0.05) in body, liver and pancreatic weights. The ingestion of fluoride by both well-fed and PU rats also caused significant reduction (p<0.05) in the body and liver weights except the weight of the pancreas. Moreover, PU increased the level of MDA in both liver and pancreas and has no significant effect on CAT in the liver whereas, its activity was reduced significantly (p<0.05) in the pancreas. The activity of SOD and GSH level were significantly reduced in the liver of PU rats compared to the control but the activity of SOD was increased in the pancreas while no effect was observed in the level of GSH. In the liver, ingestion of fluoride increased the level of MDA in PU rats but the effect was not significant in well fed rats when compared to their respective controls. In the pancreas however, ingestion of fluoride has no effect on the MDA level of both PU and well-fed rats when compared to their controls. In addition, ingestion of fluoride significantly reduced the activity of CAT in the liver of both PU and well-fed rats while in the pancreas, CAT activity was significantly reduced in PU only when compared to their respective controls. Fluoride did not affect the activity of SOD in both the liver and the pancreas of well-fed rats but there was reduction in the activity of SOD in the pancreas of PU rats and a significant increase (p<0.05) was observed in the liver. In addition, the ingestion of fluoride had no effect on GSH level in both PU and well fed rats in the liver but significant reductions were observed in the pancreas of both PU and well-fed rats when compared to their respective controls. We conclude that fluoride exerts biochemical effect on lipid peroxidation and antioxidant enzymes of both PU and well-fed rats. This effect varied widely between the liver and the pancreas but it seems that the liver is more sensitive to the toxic assault of fluoride than the pancreas especially in PU rats.en_US
dc.identifier.citation4en_US
dc.identifier.issn1996-3343
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/1092
dc.language.isoenen_US
dc.publisherScience Alerten_US
dc.relation.ispartofseries5(4);215-223
dc.subjectProtein undernutritionen_US
dc.subjectLipid peroxidationen_US
dc.subjectAntioxidanten_US
dc.subjectPancreasen_US
dc.subjectLiveren_US
dc.subjectFluorideen_US
dc.titleBiochemical Changes in the Liver and the Pancreas of Well-fed and Protein Undernourished Rats Following Fluoride Administrationen_US
dc.typeArticleen_US
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Fluoride exerts adverse effects on lipid peroxidation and antioxidant enzymes in the liver and pancreas of both protein-undernutrition and well-fed rats.
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