Comparative Amelioration of Renal Histomorphology by Ascorbic Acid and Camellia sinensis Extract in Wistar Rats Exposed to Lead-Induced Nephropathy
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Date
2020
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Annals of Medical Research
Abstract
To compare the ameliorative effects of ascorbic acid and Camellia sinensis extract on renal histomorphology of lead-induced nephropathic rats. Material and methods: Twenty four rats were randomly grouped into four groups (I–IV) as follows: Normal control group I administered distilled water (5 ml/kg), Test control group II administered lead acetate (2 mg/ml), Treated group III administered lead acetate (2 mg/ml) + ascorbic acid (100 mg/kg), Treated group IV administered lead acetate (2 mg/ml) + Camellia sinensis extract (10 mg/kg). All administrations were done through oral route and lasted for 30 days. Results: Body and renal tissue weight of study animals were significantly reduced (p < 0.05) in test control relative to normal control while treated groups showed non-significant reduction. Histological examination of renal tissue showed significant prominence of histopathological features such as inflammation, necrosis and glomerular congestion in test control group while treated groups showed marked reduction. According to the findings of this study, treatment with ascorbic acid or Camellia sinensis extract comparatively exert ameliorative effects on lead-induced nephropathy in Wistar rats which in turn culminates into reparative influence on their renal histomorphology.