Comparative Study of the Effects of Annona muricata and Tapinanthus globiferus Extracts on Biochemical Indices of Diabetic Rats
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Date
2019
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Pharmacognosy Journal
Abstract
Introduction: Annona muricata and Tapinanthus globiferus (mistletoe) are medicinal plants
used in traditional medicine to combat an array of human diseases. However, there is dearth
of scientific prove for the activity of these plants in the management of non-infectious human
diseases such as cancer, insomnia, hypertension, ulcers and diabetes. Method: The present
study was designed to assess comparatively the effects of methanol extracts of Annona
muricata (AME) and Tapinanthus globiferus (TGE) on biochemical indices of alloxan induced
diabetic rats. The animals were allocated to eight (8) groups, group I were normal non-diabetic
rats, group II (diabetic untreated group), group III treated with metformin alone, groups IV & V
were diabetic rats treated with AME at dose of concentration 200 mg/kg BW & 400 mg/kg BW
respectively, groups VI & VII were diabetic rats treated with 200 mg/kg BW & 400 mg/kg BW
of TGE respectively. Group VIII were diabetic rats treated with AME + TGE at concentration of
200 mg/kg BW each. Concentrations of serum total cholesterol (TC), high density lipoprotein
(HDL), triglyceride (TG) of alloxan diabetic rats, creatinine and urea were assayed after 21 days
of the respective treatments. Results: Diabetic untreated rats had significant increase p<0.05
in TC, TG, urea and creatinine compared to normal control group as opposed to the significant
decrease observed for HDL in diabetic rats. However, treatment of diabetic rats with AME
and TGE significantly suppressed (p<0.05) the concentrations of TC, TG and creatinine when
compared with the diabetic untreated rats. A similar trend was observed for the calculated
atherogenic index of treated rats when compared with diabetic untreated rats. Interestingly,
co-administration of AME + TGE improved the biochemical indices of diabetic rats better than
using each plant separately. Conclusion: The results of this study suggest that AME and TGE
could offer some benefits in the management of diabetic complications especially with regard
to cardiac and renal health.
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Keywords
Alloxan, Annona muricata, Diabetes, Mistletoe, Tapinanthus globiferus