Ocimum gratissimum (Linn) leaves extract attenuates oxidative stress and liver injury in gentamicin-induced hepatotoxicity in rats
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Date
2021-04-03
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Taylor and Francis
Abstract
The adverse effect of gentamicin on tissues like kidney and liver makes its use
limited in clinical settings. Ocimum gratissimum are known for many medicinal
uses. The effect of aqueous extract (AOGL) and methanolic extract (MOGL) of
Ocimum gratissimum (Linn) on liver following injury induced by gentamicin
was investigated in this study. Forty adult (40) male Wistar rats were divided
into 8 groups as follows: Group 1 (n = 5) received distilled water daily by oral
route. Groups 2, 3, 4, 5, 6, 7 and 8 (n = 5) received 100 mg/kg/day of gentamicin
i.p. for a week. After, groups 3, 4, 5, 6, 7 and 8 (n = 5) received 100, 200 and
400 mg/kg/day of AOGL and MOGL p.o, respectively, for 28 days. The rats
treated with both AOGL and MOGL for 28 days were left for a recovery period
of 14 days. Liver enzymes (ALT, AST and ALP), total bilirubin and total protein
were determined in the plasma. TBARS and GSH levels were assayed in the liver
homogenate. Gentamicin increases ALT, AST, ALP, total bilirubin and total
protein, TBARS and decreases GSH, catalase and SOD of the toxic control
when compared to the control group. Post-treatment with AOGL and MOGL
in the treated groups caused increases GSH, catalase and SOD and decreases
TBARS, ALT, AST, ALP, total bilirubin and total protein when compared with the
toxic control group. The results show that AOGL and MOGL are capable of
ameliorating liver injury caused by gentamicin in rats.
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Keywords
Ocimum gratissimum leaves