Neuroprotective Properties of NMDA R1 Antagonist (Ketamine) in Cyanide Treated Neuronsin vitro
| dc.contributor.author | Omotoso, Dayo | |
| dc.date.accessioned | 2022-05-04T14:20:56Z | |
| dc.date.available | 2022-05-04T14:20:56Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | Aims:This study aims at investigating possible means of reducing cyanide toxicity by blocking NMDA R1 via ketamine (an NMDA R1 antagonist). This is to provide a template for quick arrest of cyanide toxicity in neurons under oxygen deprived condition. Place and Duration of Study:Bingham University, Department of Anatomy, Karu, Nigeria. The duration of the study was100 minutes. Methodology:Freshly harvested cortical tissue blocks were perfused in accessory cerebrospinal fluid (ACSF) containing all the necessary salts and glucose. The cultures were treated with ACSF (Control), ACSF+KCN (potassium cyanide), ACSF+KCN+Ketamine and ACSF+Ketamine for a total duration of 100 minutes at 37ÂșC. Results:The Ketamine hada protective and reversal effects on the tissues both for oxygen deprivation and cyanide toxicity, The cells in tissues treated with ACSF+KCN+Ketamine showed normal appearance of cell body and axonal projections, the cells treated with ACSF+Ketamine showed fewer degenerating cells compared to those treated with cyanide. Conclusion:Ketamine, an NMDA R1 antagonist is neuroprotective against the toxicity of cyanide. | en_US |
| dc.identifier.uri | http://dspace.run.edu.ng:8080/jspui/handle/123456789/2631 | |
| dc.language.iso | en | en_US |
| dc.publisher | SDI | en_US |
| dc.subject | Cyanide toxicity | en_US |
| dc.subject | Neuroprotection | en_US |
| dc.subject | NMDA R1 | en_US |
| dc.title | Neuroprotective Properties of NMDA R1 Antagonist (Ketamine) in Cyanide Treated Neuronsin vitro | en_US |
| dc.type | Article | en_US |