Aneamia Following Artemisinin-Based Combination Treatments of Uncomplicated Plasmodium falciparum Malaria in Children: Temporal Patterns of Heamatocrit and the Use of Uncomplicated Hyperparasitemia as a Model for Evaluating Late Appearing Anaemia.

dc.contributor.author	Folarin, Onikepe
dc.date.accessioned	2022-05-09T08:55:38Z
dc.date.available	2022-05-09T08:55:38Z
dc.date.issued	2017
dc.description.abstract	Background: In severe malaria, intravenous artesunate may cause delayed haemolytic anaemia but there has been little evaluation of the propensity of oral artemisinin-based combination treatments (ACTs) to cause late-appearing anaemia. Methods: The frequency of anaemia (haematocrit:total parasitaemia cleared, and mean haematocrit 5 weeks after treatment began were significantly lower in hyperparasitaemic children than in children without hyperparasitaemia, suggesting haematocrit conservation during treatment followed later by a loss of haematocrit. Asymptomatic late-appearing anaemia occurred in 6% of the children. Conclusion: Artesunate-amodiaquine and artemether-lumefantrine contribute to haematocrit conservation at high parasitaemias but may cause late-appearing anaemia.	en_US
dc.identifier.uri	http://dspace.run.edu.ng:8080/jspui/handle/123456789/2836
dc.language.iso	en	en_US
dc.publisher	Chemotherapy	en_US
dc.title	Aneamia Following Artemisinin-Based Combination Treatments of Uncomplicated Plasmodium falciparum Malaria in Children: Temporal Patterns of Heamatocrit and the Use of Uncomplicated Hyperparasitemia as a Model for Evaluating Late Appearing Anaemia.	en_US
dc.type	Article	en_US

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