2-Aryl benzimidazoles: Synthesis, In vitro alpha-amylase inhibitory activity, and molecular docking study

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dc.contributor.authorAkande, Akinsola
dc.date.accessioned2022-02-01T10:34:17Z
dc.date.available2022-02-01T10:34:17Z
dc.date.issued2018-03-06
dc.description.abstractDespite of many diverse biological activities exhibited by benzimidazole scaffold, it is rarely explored for the -amylase inhibitory activity. For that purpose, 2-aryl benzimidazole derivatives 1-45 were synthesized and screened for in vitro -amylase inhibitory activity. Structures of all synthetic compounds were deduced by various spectroscopic techniques. All compounds revealed inhibition potential with IC50 values of 1.48 ± 0.38-2.99 ± 0.14 M, when compared to the standard acarbose (IC50 = 1.46 ± 0.26 M). Limited SAR suggested that the variation in the inhibitory activities of the compounds are the result of different substitutions on aryl ring. In order to rationalize the binding interactions of most active compounds with the active site of -amylase enzyme, in silico study was conducted.en_US
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/959
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectBenzimidazoleen_US
dc.subjectalpha-Amylaseen_US
dc.subjectIn vitroen_US
dc.subjectIn silicoen_US
dc.subjectStructure-activity relationship (SAR)en_US
dc.title2-Aryl benzimidazoles: Synthesis, In vitro alpha-amylase inhibitory activity, and molecular docking studyen_US
dc.typeArticleen_US
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