Harungana madagascariensis Lam ex poir (Hypericaceae) Fruits Oil Extract: Photochemistry and Acute Toxicity Evaluation

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dc.contributor.authorAjibade, Sunday
dc.date.accessioned2022-03-08T12:09:41Z
dc.date.available2022-03-08T12:09:41Z
dc.date.issued2017
dc.description.abstractThis study reports the phytochemistry of the oil obtained from the air-dried non-utilized fruits of H. madagascariensis a plant widely used in folklore medicine. The H. madagascariensis fruits oil (HMO) was obtained by de-fatting the chloroform extract of the air-dried fruits with n-hexane. The n-hexane extract further separated on a normal phase silica column to afford the HMO. The acute toxicity test was done on mice using the Lorke’s method. Selected physico-chemical properties (specific gravity, refractive index, pH, viscosity and saponification value) were evaluated using standard procedures. Characterization of the fatty acids constituents was done using Gas Chromatography-Mass (GC-MS) and Fourier Transform Infra Red (FTIR) spectroscopic techniques. The HMO (reddish oil) had LD50 > 5000 mg/kg; specific gravity = 0.918; refractive index = 1.472; pH: 6.4, Viscosity: 2.252, Saponification value (mg KOH/g): 140.5. GC-MS characterization of the HMO afforded eight fatty acids derivatives (47.93% unsaturated fatty acid and 14.82% saturated fatty acids of the total peak area): palmitic acid methyl ester (7.00%), palmitic acid (2.61%), linoleyl alcohol (1.22%), linoleic acid methyl ester (26.87%), stearic acid methyl ester (4.09%), linoleic acid (12.72%), linoleic acid ethyl ester (7.12%) and behenic acid methyl ester (1.12%). FTIR spectrum showed vibrational frequencies for: OH, C=C, C=O and C-O functional groups. Aside reporting for the first time the phytochemistry of the fruit oil of H. madagascariensis, the presence of the unsaturated fatty acids, the promising LD50 and physico-chemical properties imply application of the HMO in nutraceutics and cosmetology.en_US
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/2051
dc.language.isoenen_US
dc.publisherInternational Journal for Pharmaceutical Science and Researchen_US
dc.relation.ispartofseriesVol. 8;Issue 8
dc.subjectH. madagascariensisen_US
dc.subjectNon-utilised fruitsen_US
dc.subjectFatty acids derivativesen_US
dc.subjectCosmetologyen_US
dc.subjectToxicityen_US
dc.titleHarungana madagascariensis Lam ex poir (Hypericaceae) Fruits Oil Extract: Photochemistry and Acute Toxicity Evaluationen_US
dc.typeArticleen_US
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