PRELIMINARY TOXICOLOGICAL EVALUATION AND EFFECT OF THE SEED OIL OF HURA CREPITANS AND BLIGHIA UNIJUGATA BAK ON THE LIPID PROFILE OF RAT
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Date
2009
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University of Vigo, Faculty of Science
Abstract
A preliminary investigation of the possible toxicity effect of the seed oil of Hura crepitans
and Blighia unijugata bak was carried on histopathology, some haematological and
biochemical parameters of albino rats. The rats were divided into five groups (A, B, C and D
were fed with 5% of the test oils, E served as control without oil and F was fed with 5% of
known edible oil) and fed for twelve weeks. The phytochemical screening of these oils
reveals the presence of glycoside, steroid and flavonoid. The highest body weight gain was
found in the group fed with oil from Blighia unijugata bak (AR). There was a general
difference in the weight of the kidney of all the test groups when compared with that of the
control. No death or clinical sign of toxicity was observed in any of the groups. The study
shows no severe damage to the liver but the possibility of cellular lipotoxicity based on the
alteration of the lipid profile