Thyroid Hormones and Interference in Thyroid Function Tests: A Review

Abstract

The objective of this paper was to provide a critical and concise review on thyroid hormones and what constitutes interference in thyroid function tests using appropriate Online resources.Thethyroid function tests, play a valuable and significant role in diagnosing and managing thyroid disease. Discordance can exist between test results and symptoms, leading to false laboratory reports, misdiagnosis, and mismanagement of thyroid disease. Interference in thyroid function tests can be caused by heterophile antibodies, macro TSH, biotin interference, anti-streptavidin and anti-ruthenium antibodies, thyroid hormone antibodies, and the high dose hook effect. This review paper also discusses the importance of studying interference, the mechanical perspectives of interference, and protocols to limit or eliminate interference in thyroid function assays. Additionally, it highlights quality control and laboratory safety aspects, as well as advancements in healthcare team deliveries related to thyroid function tests.