Synthesis, Characterisation and Antimirobial Studies of Metal(II) Complexes of Trimethoprim and 2,2' Bipyridine Heterocycle

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dc.contributor.authorOyetunde, Temidayo
dc.date.accessioned2022-03-02T11:25:51Z
dc.date.available2022-03-02T11:25:51Z
dc.date.issued2021-06-14
dc.description.abstractMixed-ligand complexes of trimethoprim (TMP) with 2,2′-bipyridine (bipy) with the formular [M(TMP)(bipy)X].nH2O, where M = Mn(II), Co(II), Ni(II), Cu(II), Fe(II), Zn(II) and X= Cl/SO4, were synthesized and characterized by percentage metal, infrared, electronic spectroscopies, room temperature magnetic moments, melting points, conductance measurements and elemental analysis. From the infrared spectral data, TMP behaves as a bidentate ligand bonding to the metals via the N atom of the pyrimidine amino group (3412-3300 cm-1) and nitrogen atom of the azomethine moiety (1666-1639 cm-1) while the bipy coordinated through the diimine nitrogen atoms (1593-1404 cm-1). The room temperature magnetic moment and electronic spectra indicated that the metal(II) complexes were monomeric and octahedral. The molar conductance of the synthesised complexes in the range 24-40 Ω-1cm2 mol-1 confirmed their non-electrolytic and covalent nature. The antimicrobial studies showed that the complexes were inactive towards the tested fungus but possessed good antibacterial activities. The observed trend for the antibacterial activities demonstrated by the mixed metal complexes was in the order Mn >Zn > Cu > Fe > Co ~ Ni thus making [Mn(TMP)(bipy)Cl2].2H2O the most biologically active among them. It was also observed that antibacterial activities exhibited varied directly with concentration as the highest activities were observed at the highest concentration of 40 mg/mL.en_US
dc.identifier.urihttp://dspace.run.edu.ng:8080/jspui/handle/123456789/1754
dc.language.isoenen_US
dc.publisherNigerian Research Journal of Chemical Sciencesen_US
dc.subjectAntimicrobial, 2,2'-bipyridineen_US
dc.subjectComplexesen_US
dc.subjectHeterocycleen_US
dc.subjectTrimethoprimen_US
dc.subjectMixed-ligandsen_US
dc.titleSynthesis, Characterisation and Antimirobial Studies of Metal(II) Complexes of Trimethoprim and 2,2' Bipyridine Heterocycleen_US
dc.typeArticleen_US
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