Browsing by Author "Olamide A. Olalekan"

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    Biochemical Evaluation of potential antibacterial activities of (2,6-Diethylphenyl)-5-Oxopyrolidine Derivatives via in-silico study
    (Journal of Hunan University(Natural Sciences), 2024-07-31) Olamide A. Olalekan
    The focus of several researchers has been drawn to the surge in bacterial activity among humans and the resistance to antibacterial agents. the increasing interest in developing long-lasting antibacterial agents has been observed. therefore, the purpose of this study was to use an in- silico approach to examine the specific inhibitory activities of the of pyrrolidine derivatives against the investigated receptor. therefore, the inhibitory activities of the (2,6-diethylphenyl)-5-oxopyrrolidine derivatives were investigated using an in silico approach. In this study, various software programs were employed, including Spartan 14, AutoDock Tools, AutoDock Vina, and Discovery Studio. Compound 9 exhibits the greatest propensity to yield electrons, as indicated by the calculated HOMO, and according to LUMO and bandgap, compound 5 demonstrates the highest potential to accept electrons and exhibit superior reactivity among the other compounds studied. compounds 8 to 12 displayed the most potent ability to inhibit the bacillus cereus spor-lytic enzyme(PDB ID:4PHQ) and cytolysin A(ClyA) CC6/ 264 ox (6-303) SleL ()PDB ID: 4S3J) compared tp other studied ligands. our findings may open the door for th design of collection of proficient pyrolidine-based drug- like molecules as potential antibacterial agents.
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    Preparation and application of nickel copper ferrate and its metal–organic framework composite in the decontamination of chemical indicator contaminated synthetic and raw laboratory wastewater
    (Elsevier Results in Chemistry, 2023-09-23) Olamide A. Olalekan
    Inefficient decontamination of laboratory wastewater polluted by chemical indicators such as methyl orange (MO) and phenolphthalein (PH) is a challenge that requires attention in most developing countries. In response to this, nickel-copper ferrate (NiCuFeO4) and nickel-copper ferrate-terephthalic acid-zinc metal–organic framework composite (NiCuFeO4@MOF-5) were synthesised via simple chemical process and their activities compared for the removal of MO and PH from synthetic and raw laboratory wastewater colleccted from a science laboratory at Federal Polytechnic, Ede, Nigeria. The scanning electron micrograph (SEM) images, revealed the surfaces of NiCuFeO4 and NiCuFeO4@MOF-5 to be rough and homogeneous with tightly arranged particles that are agglomerated. The adsorption capacity of NiCuFeO4@MOF-5 expressed for the removal of MO (30.97 mg g􀀀 1) and PH (41.22 mg g􀀀 1) from aqueous solution is higher than that of NiCuFeO4 for MO (25.82 mg g􀀀 1) and PH (23.00 mg g􀀀 1). NiCuFeO4 and NiCuFeO4@MOF-5 exhibited a promising stability even at the 7th regeneration cycle for the removal of MO and PH from solution. Results obtained for the removal of MO and PH from aqueous solution by NiCuFeO4 and NiCuFeO4@MOF-5 compared favorably with reported adsorbents in literature. Conclusively, NiCuFeO4@MOF-5 is a potential and better adsorbent than NiCuFeO4 for decontaminating laboratory wastewater contaminated with MO and PH.
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    Preparation of MOF-5 imprinted chromium ferrite and its application in decontaminating metronidazole and penicillin G contaminated water system
    (Nature, 2025-05) Olamide A. Olalekan
    Metronidazole (MZ) and penicillin G (PG) are antibiotics frequently detected in aqueous systems as pollutants. Their presence in water systems is a global challenge requiring the development of sustainable solutions for water purification. Therefore, this study synthesized and improved the adsorption performance of chromium ferrite (CrFe2O4) via incorporation of metal-organic framework (MOF-5) to produce CrFe2O4@MOF-5 composite. CrFe2O4@MOF-5 and CrFe2O4 were characterized using a series of analytical instrument. Both adsorbents exhibited a four-phase mass loss from the thermogravimetric analysis, while the Brunauer-Emmett-Teller (BET) results gave a surface area of 40.94 m² g− 1 for CrFe2O4 and 59.76 m² g− 1 for CrFe2O4@MOF-5. Interestingly, microscopical images unfolded the surfaces of CrFe2O4@MOF-5 and CrFe2O4 to be heterogeneous, while elemental surface mapping confirmed the constituent elements of CrFe2O4@MOF-5 and CrFe2O4 to be Cr, Fe, O, C and Zn. CrFe2O4@MOF-5 exhibited a higher affinity (91.67 mg g− 1) for PG than CrFe2O4 (53.82 mg g− 1). Similarly, the performance of CrFe2O4@MOF-5 was better (90.24 mg g− 1) compared to CrFe2O4 (50.41 mg g− 1) towards MZ. Both Freundlich and Langmuir isotherm may describe the removal process of MZ and PG by CrFe2O4@MOF-5 while sorption of MZ and PG by CrFe2O4 fitted best for Langmuir isotherm in a sorption mechanism involving electrostatic interaction and pore diffusion. The adsorption performance of CrFe2O4@MOF-5 and its regeneration capacity compared agreeably with most published adsorbents in literature. This current study showed CrFe2O4@MOF-5 as a potential adsorbent for decontaminating MZ and PG-polluted water systems.
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    Synthesis and application of SeFe2O4@cell for the removal of polyethylene glycol from aqueous solution
    (Environmental Nanotechnology, Monitoring & Management, 2023-12-01) Olamide A. Olalekan
    Water pollution by water-soluble polymers is a severe emerging water challenge that needs urgent attention. Therefore, selenium ferrite immobilized on functionalized cellulose (SeFe2O4@Cell) was prepared for the purification of polyethylene glycol (PEG) polluted water. Characterization of SeFe2O4@Cell revealed the BET (Brunauer-Emmett-Teller) surface area to be 13.50 m2 g−1 and a total pore volume of 0.076 cm3 g−1. The crystallite size using X-ray diffraction (XRD) was 17.32 nm while the scanning electron micrograph (SEM) revealed a heterogeneous surface with irregular shaped particles. The adsorption capacity of SeFe2O4@Cell towards PEG is 39.20 mg g−1 with a percentage removal of 98%, which obeys the Freundlich isotherms. The adsorption mechanism was found to be via electrostatic interaction. The process is pseudo-second-order compliant, spontaneous, and endothermic with (1.0055 kJ mol−1) and (0.0042 kJ mol-1K−1) values within range that describes the process. Conclusively, the study presents SeFe2O4@Cell as a promising material that can be potentially used to purify water contaminated with PEG.
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    Synthesis and application of ZnO-MgO-NiO@Stearicamide mixed oxide for removal of ciprofloxacin and ampicillin from aqueous solution
    (Elsevier Results in Chemistry, 2022-07-26) Olamide A. Olalekan
    The presence of ciprofloxacin (CIP) and ampicillin (AMP) as emerging contaminant in water is a serious global challenge requiring affordable and sustainable solution. In response to this, this study prepared a mixed metal oxide, zinc oxide (ZnO)-magnesium oxide (MgO)-nickel oxide (NiO)@stearicamide for the removal of CIP and AMP from aqueous solution. The properties of ZnO-MgO-NiO@Stearicamide were confirmed with several analyses including Fourier transformed infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET), transmission electron microscopy (TEM), X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDX). ZnO-MgONiO@ Stearicamide has a BET surface area of 13.50 m2 g􀀀 1 and an average particle size of 12.50 nm. The sorption of CIP and AMP from solution by ZnO-MgO-NiO@Stearicamide showed a removal of 83.87 % and 81.10 %, respectively in a process that can be described by the Langmuir isotherm and electrostatic interaction. The sorption process has enthalpy (ΔH), entropy (ΔS) and free energy change (ΔG) which suggests the process to be spontaneous and exothermic. It is also found that synthesized metal mixed oxide could maintain a regeneration capacity that is > 80 % even after 11th regeneration cycle. The experimental findings indicate that the selfsynthesized ZnO-NiO-MgO@Stearicamide is a potential material to treat CIP- and AMP-contaminated water source.