Browsing by Author "Fajemidagba Grace Ayobami"

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    Coffe and Parkinson disease
    (Progress in Brain Research, Elsevier, 2024) Fajemidagba Grace Ayobami
    Parkinson's disease (PD) is a prevalent neurodegenerative disease marked by dopaminergic neuronal loss and misfolded alpha-synuclein (α-syn) accumulation, which results in both motor and cognitive symptoms. Its occurrence grows with age, with a larger prevalence among males. Despite substantial study, effective medicines to reduce or stop the progression of diseases remain elusive. Interest has grown in examining dietary components, such as caffeine present in coffee, for potential medicinal effects. Epidemiological studies imply a lower incidence of PD with coffee drinking, attributable to caffeine's neuroprotective abilities. Beyond caffeine, coffee constituent like chlorogenic acid and cafestol have anti-Parkinsonian benefits. Moreover, coffee use has been related with variations in gut microbiota composition, which may reduce intestinal inflammation and prevent protein misfolding in enteric nerves, perhaps through the microbiota-gut-brain axis. This review gives a summary of the neuroprotective effects of coffee, investigating both its motor and non-motor advantages in individuals with PD as well as in experimental models of PD. We reviewed some bioactive constituents of coffee, their respective interactions with misfolded α-syn accumulation, and its emerging mechanisms associated to the gut microbiome.
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    Effect of lauric acid on cognitive impairement in scopolamine -induced Alzheimer's disese-like rat model
    (Nutritional Neuroscience, 2025) Fajemidagba Grace Ayobami
    Background: Alzheimer’s disease (AD) is a multi-factorial type of dementia that poses a social and medical burden in that no effective treatment has been achieved yet. Impaired brain glucose metabolism is one of the major pathophysiological factors linked to its onset and progression. Lauric acid (LA) is a triglyceride with medium chain that can produce ketone body utilize by the brain as an alternative energy source. Objective: Therefore, the present study was carried out with the purpose of evaluating the effect of LA on cognitive impairments in scopolamine-induced AD-like rat model. Methods: Forty-two male Wistar rats were divided into six groups to receive normal saline, scopolamine, scopolamine with Donepezil, and scopolamine with varied doses of LA for a period of 21 days. Morris water maze (MWM) and Elevated Plus Maze (EPM) tests were performed to evaluate cognitive performance. After, brains were harvested and processed to assay for the level of malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), acetylcholinesterase (AChE) and interleukin-6 (IL-6). Histological analyses using Haematoxylin and eosin staining was also performed. Results: The LA-treated groups demonstrated memory retention in the MWM and EPM tests, and showed increased levels of CAT, SOD, and GSH similar to the Donepezil group, in contrast to the scopolamine only group while MDA levels, IL-6, and AChE activity were reduced in the LA treated groups contrasted to scopolamine only group. LA reduces oxidative stress, neuroinflammation, and AChE activity, which indicates a possible ability of LA to protect against AD
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    Effects of n-Hexane Extracts of Ocimum gratissimum and Momordica charantia Leaves on Learning and Memory in Scopolamine-induced Rat Model of Dementia
    (LASU Journal of Medical Sciences, 2019) Fajemidagba Grace Ayobami
    Objective: Cholinesterase inhibitors such as donepezil are being used to improve memory in people with dementia, but adverse effects associated with the use of these drugs coupled with cost have limited their use, hence the need to explore options in medicinal plants for the treatment of dementia. The aim of this study was to investigate the memory restorative effects of n-hexane extracts of Ocimum gratissimum (OG) and Momordica charantia (MC) in scopolamine-induced dementia in Wistar rats. Methods: Thirty male Wistar rats were randomly divided into six treatment groups as follows: Control, Scopolamine only (1  mg/kg  b.w), Donepezil (2  mg/kg  b.w) + scopolamine (1  mg/kg  b.w), OG (400 mg/kg b.w) + scopolamine (1 mg/kg b.w), MC (400 mg/kg b.w) + scopolamine (1 mg/kg b.w) and co-administration of OG and MC (400 mg/kg b.w each) + scopolamine (1 mg/kg b.w). The animals were treated for 15 days. Morris water maze, light and dark box test were conducted to evaluate learning and memory. Malondialdehyde (MDA) level and Acetylcholinesterase (AchE) activities were also assessed using thiobarbituric acid procedure and Ellman method respectively. Results: The result showed a significant reduction in escape latency, MDA level, AchE activity and a significant increase in the probing frequency in OG + scopolamine; MC + scopolamine and OG, MC + scopolamine treated groups when compared to the scopolamine only group (p<0.05). There was no significant difference in the escape latency, MDA, AchE activity and probing frequency between the extracts treated groups and donepenzil group. Conclusion: The study concludes that n-hexane leaves extracts of OG and MC have the ability to restore memory impairment induced by scopolamine.